Department of Otorhinolaryngology-Head and Neck Surgery, Beijing Anzhen Hospital, Capital Medical University, Beijing, P.R. China.
Acta Otolaryngol. 2023 Apr;143(4):296-300. doi: 10.1080/00016489.2023.2185290. Epub 2023 Mar 10.
There have been few studies to date exploring prognostic outcomes associated with idiopathic sudden sensorineural hearing loss (ISSNHL) in order adults.
This investigation was designed to explore the relationship between atherosclerosis-related risk factors and ISSNHL outcomes among older individuals.
In total, 172 older adults diagnosed ISSNHL from 2016 to 2021 were retrospectively evaluated to compare demographic and clinical test results.
Relative to healthy controls, ISSNHL patients exhibited significant differences in hypertension incidence and factors related to coagulation. With respect to prognosis, age, onset days, hypertension, the degree of hearing loss, type of hearing curve, fibrinogen and D-dimer levels were significant univariate prognostic factors, whereas multivariate logistic analysis showed that hypertension ( = .005) and D-dimer concentration ( = .000) were related to the treatment outcome of older ISSNHL patients. The area under the curve (AUC) for D-dimer levels was 0.795 (95% CI: 0.724-0.866). When using a D-dimer cut-off threshold value of 107.5 ng/mL, the sensitivity and specificity values of 77.0% and 76.7%.
The present results indicate that hypertension incidence and D-dimer levels may be presented as an important prognostic indicator in older affected ISSNHL individuals.
目前为止，很少有研究探索与成人特发性突发性聋（ISSNHL）相关的预后结果。
本研究旨在探讨动脉粥样硬化相关危险因素与老年 ISSNHL 患者预后的关系。
回顾性评估了 2016 年至 2021 年间诊断为 ISSNHL 的 172 名老年患者，以比较其人口统计学和临床检查结果。
与健康对照组相比，ISSNHL 患者的高血压发病率和与凝血相关的因素存在显著差异。就预后而言，年龄、发病天数、高血压、听力损失程度、听力曲线类型、纤维蛋白原和 D-二聚体水平是显著的单因素预后因素，而多因素 logistic 分析表明，高血压（ = .005）和 D-二聚体浓度（ = .000）与老年 ISSNHL 患者的治疗结果相关。D-二聚体水平的曲线下面积（AUC）为 0.795（95%CI：0.724-0.866）。当使用 D-二聚体截断值 107.5 ng/mL 时，其灵敏度和特异性分别为 77.0%和 76.7%。
本研究结果表明，高血压发病率和 D-二聚体水平可能是老年 ISSNHL 患者的重要预后指标。
