Department of Food Biotechnology and Environmental Science, Kangwon National University, Chuncheon, Korea.
Department of Food Science and Biotechnology, College of Life Science, CHA University, Seongnam, Korea.
J Med Food. 2023 Apr;26(4):232-243. doi: 10.1089/jmf.2022.K.0138. Epub 2023 Mar 10.
, belonging to the family, is an edible widely distributed perennial brown marine alga that is rich in polyphenols. Dieckol, a bioactive component of the E. stolonifera extract (ESE), is a major phlorotannin compound found only in brown algae. This study aimed to evaluate the ability of ESE to inhibit lipid accumulation caused by oxidative stress in 3T3-L1 adipocytes and high-fat diet-fed obese ICR mice. We report that ESE-treated obese ICR mice, which were fed a high-fat diet, showed reduced whole-body and adipose tissue weights with improved plasma lipid profiles. and studies have indicated that ESE inhibited the expression of adipogenesis-related genes associated with fat accumulation through AMP-activated protein kinase activity and increased the expression of lipolysis-related genes. In addition, ESE reduced the expression of enzymes involved in reactive oxygen species (ROS) production and increased the expression of antioxidant enzymes, thereby reducing ROS levels. These findings suggest that ESE possesses strong antioxidant properties and inhibits oxidative stress-induced lipid accumulation by reducing ROS production during adipocyte generation.
裙带菜，隶属于翅藻科裙带菜属，是一种广泛分布的可食用多年生褐藻，富含多酚。裙带菜中提取的岩藻黄质（ESE）的生物活性成分之一——二碘酚，是一种仅存在于褐藻中的主要的聚多酚化合物。本研究旨在评估裙带菜提取物（ESE）抑制 3T3-L1 脂肪细胞氧化应激引起的脂质积累的能力，以及在高脂饮食喂养肥胖 ICR 小鼠模型中的作用。我们报告称，高脂饮食喂养的 ESE 处理肥胖 ICR 小鼠，其全身和脂肪组织重量减轻，血浆脂质谱得到改善。研究表明，ESE 通过激活 AMP 激活的蛋白激酶活性，抑制与脂肪积累相关的脂肪生成相关基因的表达，并增加脂肪分解相关基因的表达，从而抑制脂肪生成。此外，ESE 降低了参与活性氧（ROS）产生的酶的表达，增加了抗氧化酶的表达，从而降低了 ROS 水平。这些发现表明，ESE 具有强大的抗氧化特性，通过减少脂肪生成过程中 ROS 的产生，抑制氧化应激诱导的脂质积累。
