Department of Food Science and Biotechnology, College of Life Science, CHA University, Seongnam, Gyeonggi 13488, Korea.
Naturalway, Pocheon, Gyeonggi 11160, Korea.
Cells. 2020 Apr 2;9(4):871. doi: 10.3390/cells9040871.
Obesity develops due to an energy imbalance and manifests as the storage of excess triglyceride (TG) in white adipose tissue (WAT). Recent studies have determined that edible natural materials can reduce lipid accumulation and promote browning in WAT. We aimed to determine whether extract (ESE) would increase the energy expenditure in high-fat diet (HFD)-induced obese mice and 3T3-L1 cells by upregulating lipolysis and browning. ESE is an edible brown marine alga that belongs to the family Laminariaceae and contains dieckol, a phlorotannin. We report that ESE inhibits body mass gain by regulating the expression of proteins involved in adipogenesis and lipogenesis. In addition, ESE activates protein kinase A (PKA) and increases the expression of lipolytic enzymes including adipose triglyceride lipase (ATGL), phosphorylated hormone-sensitive lipase (p-HSL), and monoacylglycerol lipase (MGL) and also thermogenic genes, such as carnitine palmitoyltransferase 1 (CPT1), PR domain-containing 16 (PRDM16), and uncoupling protein 1 (UCP1). These findings indicate that ESE may represent a promising natural means of preventing obesity and obesity-related metabolic diseases.
肥胖是由于能量失衡引起的，表现为白色脂肪组织（WAT）中过量甘油三酯（TG）的储存。最近的研究表明，可食用的天然物质可以减少脂肪积累并促进 WAT 的褐变。我们旨在确定是否 提取物（ESE）通过上调脂肪分解和褐变来增加高脂肪饮食（HFD）诱导肥胖小鼠和 3T3-L1 细胞的能量消耗。ESE 是一种可食用的棕色海洋藻类，属于褐藻科，含有岩藻黄素，一种多酚。我们报告说，ESE 通过调节参与脂肪生成和脂肪生成的蛋白质的表达来抑制体重增加。此外，ESE 激活蛋白激酶 A（PKA）并增加脂肪酶的表达，包括脂肪甘油三酯脂肪酶（ATGL）、磷酸化激素敏感脂肪酶（p-HSL）和单酰基甘油脂肪酶（MGL），以及解偶联蛋白 1（UCP1）等产热基因。这些发现表明，ESE 可能代表一种有前途的天然手段，可预防肥胖和肥胖相关的代谢疾病。
