Columbia University Vagelos College of Physicians and Surgeons New York, NY.
Bernard and Shirlee Brown Glaucoma Research Laboratory, Department of Ophthalmology, Edward S. Harkness Eye Institute, Columbia University Irving Medical Center.
J Glaucoma. 2023 Jun 1;32(6):533-539. doi: 10.1097/IJG.0000000000002205. Epub 2023 Mar 3.
Remote contrast sensitivity (CS) testing through a free downloadable home test correlates with glaucomatous macular damage measured by 10-2 visual field (VF) testing.
To assess the feasibility and validity of home CS monitoring as a measure of glaucomatous damage using a free downloadable smartphone application.
Twenty-six participants were asked to remotely use the Berkeley Contrast Squares (BCS) application, a free downloadable tool that records the user's CS for varying degrees of visual acuity. An instructional video detailing how to download and use the application was sent to the participants. Subjects were asked to send logarithmic CS results with a minimum 8-week test-retest window, and test-retest reliability was measured. Results were validated against office-based CS testing that was collected within the previous 6 months. Validity analysis was also carried out to determine whether CS as measured by BCS is a good predictor of 10-2 and 24-2 VF mean deviation (MD).
There was a high BCS test-retest reliability with an intraclass correlation coefficient score of 0.91 and a significant correlation between repeat test results and baseline test scores (Pearson, 0.86, P < 0.0001). There was significant agreement between unilateral CS scores as measured by BCS and office-based CS testing ( b = 0.94, P < 0.0001, 95% CI: 0.61 to 1.27). Unilateral CS as measured by BCS was significantly associated with 10-2 VF MD ( r2 = 0.27, P = 0.006, 95% CI: 3.7 to 20.6), but not with 24-2 VF MD ( P = 0.151).
This study suggests that a free, rapid home CS test correlates with glaucomatous macular damage as measured by 10-2 VF.
通过免费下载的家庭测试进行远程对比敏感度 (CS) 测试与通过 10-2 视野 (VF) 测试测量的青光眼性黄斑损伤相关。
评估使用免费下载的智能手机应用程序进行家庭 CS 监测作为青光眼损伤测量的可行性和有效性。
要求 26 名参与者远程使用 Berkeley Contrast Squares (BCS) 应用程序，这是一个免费下载的工具，可记录用户不同视力水平的 CS。向参与者发送了详细说明如何下载和使用应用程序的教学视频。要求参与者发送具有至少 8 周测试-重测窗口的对数 CS 结果，并测量测试-重测的可靠性。结果与在过去 6 个月内收集的基于办公室的 CS 测试进行了验证。还进行了有效性分析，以确定 BCS 测量的 CS 是否是 10-2 和 24-2 VF 平均偏差 (MD) 的良好预测指标。
BCS 具有很高的测试-重测可靠性，组内相关系数得分为 0.91，重复测试结果与基线测试得分之间存在显著相关性（Pearson，0.86，P<0.0001）。BCS 测量的单侧 CS 分数与基于办公室的 CS 测试之间存在显著一致性（b=0.94，P<0.0001，95%CI：0.61 至 1.27）。BCS 测量的单侧 CS 与 10-2 VF MD 显著相关（ r2 = 0.27，P = 0.006，95%CI：3.7 至 20.6），但与 24-2 VF MD 无关（ P = 0.151）。
这项研究表明，一种免费的、快速的家庭 CS 测试与通过 10-2 VF 测量的青光眼性黄斑损伤相关。
