Stromal Changes in Colon Blastomogenesis Associated with Development of Hypoxia in the Foci of Dysplasia.

We studied the features of reaction of the colon stromal cells (lymphohistiocytic population, fibroblasts, and blood vessels) to the appearance and progression of dysplasia in the colon epithelium against the background of increasing ischemia in the colon mucosa. The morphological material from 92 patients treated for benign processes and colon cancer in 2002-2016 was examined. Common histological methods and a complex immunohistochemical staining were used. The stromal cells of the colon mucosa, mainly lymphohistiocytic cells, undergo certain quantitative changes specific for each type of cells during progression of dysplasia and aggravation of ischemia in the mucosa. Some cells, e.g. plasma cells, presumably contribute to tissue hypoxia in the stroma. Most stromal cells, except interdigitating S100 dendritic cells and CD10 fibroblasts, decreased at the stage of grave dysplasia and cancer in situ. Low effectiveness of the immune defense can be partly explained by impairment of the function of stromal cells as a result of hypoxia in the microenvironment.