Medical Biotechnology Department, Faculty of Advanced Medical Science, Tabriz University of Medical Sciences, Tabriz, Iran.
Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Anticancer Agents Med Chem. 2021;21(1):3-19. doi: 10.2174/1871520620666200817103219.
Angiogenesis is one of the critical physiological processes, by which the new blood vessels are generated from the pre-existing vessels in the early stage of vasculogenesis. While normal angiogenesis is critical for development and tissue growth, pathologic angiogenesis is important for the growth and spread of cancers by supplying nutrients and oxygen as well as providing a conduit for distant metastasis. In the last two decades, angiogenesis has been the area of extensive researches, indicating antiangiogenic target therapy as an effective strategy for cancer therapy. At present, this field has become a major avenue for research and development of novel therapeutics.
This review is dedicated to an updated review of the most prominent antiangiogenic agents, emphasizing the novel advancements and their applications, in particular, in the fields of antibodies, peptides, vaccines, endogenous inhibitors, Nanoparticles (NPs), antiangiogenic oligonucleotides and small molecules. Also, the potential role of 3D microfluidic models as an affordable and time-saving tool for angiogenesis investigations are discussed.
Firstly, we collected and summarized new developments that have occurred in all review and research articles in databases. Then, we used important keywords related to antiangiogenic target therapy and their applications for retrieval of most relevant data.
This review is based on recent research and review articles and intended to cover all newly discovered agents inhibiting tumor angiogenesis and in particular, VEGF.
New research studies have shown that anti-angiogenesis agents especially, in the form of combination therapy are effective in various cancers treatment.
血管生成是一个关键的生理过程，在此过程中，新的血管从血管发生早期的预先存在的血管中产生。虽然正常的血管生成对于发育和组织生长至关重要，但病理性血管生成对于癌症的生长和扩散非常重要，因为它为肿瘤提供营养和氧气，并为远处转移提供通道。在过去的二十年中，血管生成已经成为广泛研究的领域，表明抗血管生成靶向治疗是癌症治疗的有效策略。目前，这个领域已经成为新型治疗药物研发的主要途径。
本文旨在对最显著的抗血管生成剂进行更新的综述，强调新的进展及其应用，特别是在抗体、肽、疫苗、内源性抑制剂、纳米粒子（NPs）、抗血管生成寡核苷酸和小分子等领域。此外，还讨论了 3D 微流控模型作为一种经济实惠且节省时间的血管生成研究工具的潜在作用。
首先，我们收集并总结了数据库中所有综述和研究文章中出现的新进展。然后，我们使用了与抗血管生成靶向治疗及其应用相关的重要关键词，以检索最相关的数据。
本综述基于最近的研究和综述文章，旨在涵盖所有新发现的抑制肿瘤血管生成的药物，特别是 VEGF。
新的研究表明，抗血管生成药物，特别是联合治疗形式，在各种癌症的治疗中是有效的。
