Isarangkura P, Pintadit P, Hathirat P, Sasanakul W
Department of Pediatrics, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Birth Defects Orig Artic Ser. 1987;23(5A):395-401.
Platelet changes in thalassemia included prolongation of bleeding time (30%), thrombocytosis (29%), decreased platelet retention (79%), and normal PF3 release. Platelet aggregation was found to be hyperaggregation in 50%, normal in 22%, and hypoaggregation in 28% of the studied patients. Platelet changes in thalassemia can be hyper-, normal, or hypofunction. The changes are likely to be related to many factors, particularly to the progress of the disease. Platelet hypoaggregation may lead to a bleeding problem. Platelet hyperaggregation and thrombocytosis were prominent in the splenectomized patients and/or the severely anemic group; antiplatelet drugs may be indicated in these patients.
地中海贫血患者的血小板变化包括出血时间延长（30%）、血小板增多（29%）、血小板滞留能力降低（79%）以及PF3释放正常。在所研究的患者中，发现50%的患者血小板聚集为高聚集，22%为正常，28%为低聚集。地中海贫血患者的血小板变化可为高功能、正常功能或低功能。这些变化可能与许多因素有关，尤其是与疾病进展有关。血小板低聚集可能导致出血问题。血小板高聚集和血小板增多在脾切除患者和/或重度贫血组中较为突出；这些患者可能需要使用抗血小板药物。
