Department of Obstetrics and Gynecology, Faculty of Medicine, Baskent University, Ankara, Turkey.
J Obstet Gynaecol. 2023 Dec;43(1):2186776. doi: 10.1080/01443615.2023.2186776.
The aim of the study is to compare the perinatal outcomes of twin pregnancies resulting from assisted reproductive technology (ART) treatment in which granulocyte colony-stimulating factor (G-CSF) was used with those in which it was not. In this retrospective study, the clinical data of 122 dichorionic diamniotic twin pregnancies were reviewed. Pregnancies were divided into two groups, G-CSF-treated and non-G-CSF treated. Maternal age, gestational week at birth, oligohydramnios, gestational hypertension, pre-eclampsia, preterm birth, first-trimester bleeding, gestational diabetes, rupture of membrane, foetal congenital anomalies, admission to the neonatal intensive care unit, birth weight (BW), small for gestational age, BW discordance, Apgar score and placental weight were compared between the groups.IMPACT STATEMENT Granulocyte colony-stimulating factor (G-CSF) administrations increase pregnancy outcomes and do not have a negative effect on perinatal outcomes in singleton pregnancies. This study showed that the perinatal outcome of dichorionic diamniotic twin pregnancies conceived after assisted reproductive technology (ART) treatment was similar in the GSF administrated and non-GSF administrated groups. Using G-CSF to increase the success of ART does not seem to have an adverse outcome in the dichorionic diamniotic twin pregnancies.
本研究旨在比较使用粒细胞集落刺激因子（G-CSF）与未使用 G-CSF 的辅助生殖技术（ART）治疗的双胎妊娠的围产结局。在这项回顾性研究中，回顾了 122 例双绒毛膜双羊膜囊双胎妊娠的临床资料。将妊娠分为 G-CSF 治疗组和非 G-CSF 治疗组。比较两组间产妇年龄、出生时的孕周、羊水过少、妊娠期高血压、子痫前期、早产、孕早期出血、妊娠期糖尿病、胎膜早破、胎儿先天性畸形、新生儿重症监护病房入院、出生体重（BW）、小于胎龄儿、BW 不匀、阿普加评分和胎盘重量。粒细胞集落刺激因子（G-CSF）的应用增加了妊娠结局，对单胎妊娠的围产结局没有负面影响。本研究表明，ART 治疗后受孕的双绒毛膜双羊膜囊双胎妊娠的围产结局在 GSF 治疗组和非 GSF 治疗组相似。使用 G-CSF 提高 ART 的成功率似乎不会对双绒毛膜双羊膜囊双胎妊娠产生不良后果。
