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通过TGF-β和NF-κB途径对PM诱导的BALB/c小鼠肺损伤的保护作用

Protective Effect of on PM-Induced Pulmonary Damage in BALB/c Mice via the TGF-β and NF-κB Pathway.

作者信息

Lee Hyo Lim, Kim Jong Min, Go Min Ji, Kim Tae Yoon, Joo Seung Gyum, Kim Ju Hui, Lee Han Su, Kim Hyun-Jin, Heo Ho Jin

机构信息

Division of Applied Life Science (BK21), Institute of Agriculture and Life Science, Gyeongsang National University, Jinju 52828, Republic of Korea.

出版信息

Antioxidants (Basel). 2023 Apr 20;12(4):968. doi: 10.3390/antiox12040968.

DOI:10.3390/antiox12040968
PMID:37107342
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10135714/
Abstract

This study aimed to assess the protective effect of an extract of against particulate-matter (PM)-induced pulmonary inflammation and fibrosis. The compounds with physiological activity were identified as shanzhiside, secologanoside, loganic acid, chlorogenic acid, secologanic acid, secoxyloganin, quercetin pentoside, and dicaffeoyl quinic acids (DCQA), including 3,4-DCQA, 3,5-DCQA, 4,5-DCQA, and 1,4-DCQA using ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF/MS). The extract of reduced cell death, reactive oxygen species (ROS) production, and inflammation in A549 cells. The extract of decreased serum T cells, including CD4 T cells, CD8 T cells, and total T helper 2 (Th2) cells, and immunoglobulins, including immunoglobulin G (IgG) and immunoglobulin E (IgE), in PM-induced BALB/c mice. The extract of protected the pulmonary antioxidant system by regulating superoxide dismutase (SOD) activity, reduced glutathione (GSH) contents, and malondialdehyde (MDA) levels. In addition, it ameliorated mitochondrial function by regulating the production of ROS, mitochondrial membrane potential (MMP), and ATP contents. Moreover, the extract of exhibited a protective activity of apoptosis, fibrosis, and matrix metalloproteinases (MMPs) via TGF-β and NF-κB signaling pathways in lung tissues. This study suggests that the extract of might be a potential material to improve PM-induced pulmonary inflammation, apoptosis, and fibrosis.

摘要

本研究旨在评估[提取物名称]提取物对颗粒物（PM）诱导的肺部炎症和纤维化的保护作用。使用超高效液相色谱-四极杆飞行时间质谱（UPLC-Q-TOF/MS）鉴定出具有生理活性的化合物为山栀苷、裂环马钱子苷、马钱子酸、绿原酸、裂环马钱子酸、裂环氧化马钱子苷、槲皮素戊糖苷和二咖啡酰奎宁酸（DCQA），包括3,4-DCQA、3,5-DCQA、4,5-DCQA和1,4-DCQA。[提取物名称]提取物减少了A549细胞中的细胞死亡、活性氧（ROS）生成和炎症。[提取物名称]提取物降低了PM诱导的BALB/c小鼠血清中的T细胞，包括CD4 T细胞、CD8 T细胞和总辅助性T细胞2（Th2）细胞，以及免疫球蛋白，包括免疫球蛋白G（IgG）和免疫球蛋白E（IgE）。[提取物名称]提取物通过调节超氧化物歧化酶（SOD）活性、还原型谷胱甘肽（GSH）含量和丙二醛（MDA）水平来保护肺部抗氧化系统。此外，它通过调节ROS生成、线粒体膜电位（MMP）和ATP含量来改善线粒体功能。此外，[提取物名称]提取物在肺组织中通过TGF-β和NF-κB信号通路表现出对细胞凋亡、纤维化和基质金属蛋白酶（MMPs）的保护活性。本研究表明，[提取物名称]提取物可能是改善PM诱导的肺部炎症、细胞凋亡和纤维化的潜在物质。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e340/10135714/37d7dd66b45d/antioxidants-12-00968-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e340/10135714/728ae356dbe4/antioxidants-12-00968-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e340/10135714/9eac86c78d7c/antioxidants-12-00968-g002a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e340/10135714/eb24e2303391/antioxidants-12-00968-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e340/10135714/d84ec2f94cbf/antioxidants-12-00968-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e340/10135714/04bbcfa34ff1/antioxidants-12-00968-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e340/10135714/e0cb785dd378/antioxidants-12-00968-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e340/10135714/09b48c50f1da/antioxidants-12-00968-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e340/10135714/7cf4924e5673/antioxidants-12-00968-g008a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e340/10135714/589b5d29feb5/antioxidants-12-00968-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e340/10135714/37d7dd66b45d/antioxidants-12-00968-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e340/10135714/728ae356dbe4/antioxidants-12-00968-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e340/10135714/9eac86c78d7c/antioxidants-12-00968-g002a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e340/10135714/eb24e2303391/antioxidants-12-00968-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e340/10135714/d84ec2f94cbf/antioxidants-12-00968-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e340/10135714/04bbcfa34ff1/antioxidants-12-00968-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e340/10135714/e0cb785dd378/antioxidants-12-00968-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e340/10135714/09b48c50f1da/antioxidants-12-00968-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e340/10135714/7cf4924e5673/antioxidants-12-00968-g008a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e340/10135714/589b5d29feb5/antioxidants-12-00968-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e340/10135714/37d7dd66b45d/antioxidants-12-00968-g010.jpg

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