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[神经节苷脂对小鼠抵抗狂犬病病毒的作用]

[Effect of gangliosides on the resistance of mice to the rabies virus].

作者信息

Krasnopol'skiĭ Iu M, Shvets V I

出版信息

Biull Eksp Biol Med. 1987 Dec;104(12):698-9.

PMID:3689963
Abstract

The survival of animals has been studied after their infection with a mixture of rabies virus and gangliosides isolated from various organs. It has been found that virus incubation with a summarized fraction of cerebral gangliosides increased considerably the survival of animals. At the same time it was shown that gangliosides from cattle spleen and red blood cells taken in the same proportions as cerebral gangliosides, do not have any protective effect. The in vivo study of the antiviral ganglioside activity has been performed.

摘要

在动物感染狂犬病病毒与从各种器官分离出的神经节苷脂的混合物后,对其存活情况进行了研究。已发现病毒与脑源性神经节苷脂的汇总级分一起孵育可显著提高动物的存活率。同时还表明,以与脑源性神经节苷脂相同比例摄取的牛脾脏和红细胞中的神经节苷脂没有任何保护作用。已进行了抗病毒神经节苷脂活性的体内研究。

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