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[神经节苷脂对小鼠抵抗狂犬病病毒的作用]

[Effect of gangliosides on the resistance of mice to the rabies virus].

作者信息

Krasnopol'skiĭ Iu M, Shvets V I

出版信息

Biull Eksp Biol Med. 1987 Dec;104(12):698-9.

PMID:3689963
Abstract

The survival of animals has been studied after their infection with a mixture of rabies virus and gangliosides isolated from various organs. It has been found that virus incubation with a summarized fraction of cerebral gangliosides increased considerably the survival of animals. At the same time it was shown that gangliosides from cattle spleen and red blood cells taken in the same proportions as cerebral gangliosides, do not have any protective effect. The in vivo study of the antiviral ganglioside activity has been performed.

摘要

在动物感染狂犬病病毒与从各种器官分离出的神经节苷脂的混合物后,对其存活情况进行了研究。已发现病毒与脑源性神经节苷脂的汇总级分一起孵育可显著提高动物的存活率。同时还表明,以与脑源性神经节苷脂相同比例摄取的牛脾脏和红细胞中的神经节苷脂没有任何保护作用。已进行了抗病毒神经节苷脂活性的体内研究。

相似文献

1
[Effect of gangliosides on the resistance of mice to the rabies virus].[神经节苷脂对小鼠抵抗狂犬病病毒的作用]
Biull Eksp Biol Med. 1987 Dec;104(12):698-9.
2
Involvement of gangliosides in rabies virus infection.
J Gen Virol. 1986 Jan;67 ( Pt 1):47-56. doi: 10.1099/0022-1317-67-1-47.
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[Action of phospholipids and gangliosides on tumor cell sensitivity to the cytostatic and membrane-toxic action of splenic effectors].[磷脂和神经节苷脂对肿瘤细胞对脾效应细胞的细胞抑制和膜毒性作用敏感性的影响]
Biull Eksp Biol Med. 1985 Aug;100(8):237-9.
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Immunosuppression in rabies virus infection mediated by lymphocyte apoptosis.淋巴细胞凋亡介导的狂犬病病毒感染中的免疫抑制
Jpn J Infect Dis. 2001 Aug;54(4):144-7.
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The role of gangliosides in the interaction of a growth inhibitor with mouse LM cells.神经节苷脂在生长抑制剂与小鼠LM细胞相互作用中的作用。
J Cell Physiol. 1985 Dec;125(3):427-35. doi: 10.1002/jcp.1041250310.
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Expansion of natural killer cells in mice transgenic for IgM antibody to ganglioside GD2: demonstration of prolonged survival after challenge with syngeneic tumor cells.针对神经节苷脂GD2的IgM抗体转基因小鼠中自然杀伤细胞的扩增:同基因肿瘤细胞攻击后长期存活的证明。
Int J Oncol. 2003 Aug;23(2):381-8.
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Extraction and purification of gangliosides from CER cells, a cell line suitable for rabies virus replication.从适合狂犬病病毒复制的细胞系CER细胞中提取和纯化神经节苷脂。
Microbiologica. 1990 Oct;13(4):339-42.
8
Specific neutralization value for rabies virus of different tissue extracts from immunized mice refractory to severe infection with Babeş rabies fixed virus.
Arch Roum Pathol Exp Microbiol. 1981 Oct-Dec;40(4):317-22.
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Gangliosides influence experimental influenza virus infection in mice.神经节苷脂影响小鼠实验性流感病毒感染。
J Gen Virol. 1989 Sep;70 ( Pt 9):2433-7. doi: 10.1099/0022-1317-70-9-2433.
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Cytosolic gangliosides of rat brain: their fractionation into protein-bound complexes of different ganglioside compositions.大鼠脑的胞质神经节苷脂:它们被分离成具有不同神经节苷脂组成的蛋白质结合复合物。
J Neurosci Res. 1984;12(2-3):193-204. doi: 10.1002/jnr.490120207.

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