Hochberg M C
Department of Community Medicine, United Medical School of Guy's Hospital, London.
Br J Rheumatol. 1987 Dec;26(6):437-41. doi: 10.1093/rheumatology/26.6.437.
Mortality rates from systemic lupus erythematosus (SLE) in England and Wales were estimated from Office of Population Censuses and Surveys data from 1974 to 1983, by age and sex. Age-specific average annual mortality rates showed unimodal distributions for both sexes with maximal death rates in the 65-74-year age groups. The overall age-adjusted mortality rate for females was about four times that in males, 3.94 versus 1.02 per million person-years, respectively. Examination of individual age-specific rates showed an early sharp rise in females producing female-to-male ratios which exceeded 10 in the 25-34-year age group. Age-adjusted annual mortality rates in females significantly declined during the 10-year interval studied from 4.47 to 2.99 per million person-years (p = 0.0083). These patterns of mortality from SLE observed in England and Wales are comparable to those reported among Caucasians in the United States during a similar time period.
利用1974年至1983年人口普查与调查办公室的数据，按年龄和性别估算了英格兰和威尔士系统性红斑狼疮（SLE）的死亡率。特定年龄的年均死亡率显示，两性均呈单峰分布，65 - 74岁年龄组的死亡率最高。女性的总体年龄调整死亡率约为男性的四倍，分别为每百万人年3.94例和1.02例。对各特定年龄死亡率的研究表明，女性早期死亡率急剧上升，在25 - 34岁年龄组中，女性与男性的死亡率之比超过10。在研究的10年期间，女性的年龄调整年死亡率从每百万人年4.47例显著下降至2.99例（p = 0.0083）。在英格兰和威尔士观察到的这些SLE死亡率模式与同期美国白种人中报告的模式相当。
