Department of Cardiac Thoracic Vascular Sciences and Public Health, University of Padua, 35131 Padua, Italy.
Department for Woman and Child Health, University of Padua, 35128 Padua, Italy.
Int J Environ Res Public Health. 2023 Mar 4;20(5):4565. doi: 10.3390/ijerph20054565.
Respiratory Syncytial Virus (RSV) is a known cause of acute lower respiratory infections in infants and young children. The present study aims to analyze the temporal trends and characteristics of hospitalization related to RSV in the Veneto region (Italy) in the period between 2007 and 2021. The analysis is performed on all the hospital discharge records (HDRs) of public and accredited private hospitals corresponding to hospitalizations occurring in the Veneto region (Italy). HDRs are considered if they included at least one of the following ICD9-CM codes: 079.6-Respiratory Syncytial Virus (RSV); 466.11-acute bronchiolitis due to RSV; and 480.1-pneumonia due to RSV. Total annual cases, sex, and age-specific rates and trends are evaluated. Overall, an increasing trend in the number of hospitalizations due to RSV was observed between 2007 and 2019, with a slight drop in RSV seasons 2013-2014 and 2014-2015. From March 2020 to September 2021, almost no hospitalization was registered, but in the last quarter of 2021, the number of hospitalizations reached its highest value in the series. Our data confirm the preponderance of RSV hospitalizations in infants and young children, the seasonality of RSV hospitalizations, and acute bronchiolitis as the most frequent diagnosis. Interestingly, the data also show the existence of a significant burden of disease and a non-negligible number of deaths also in older adults. The present study confirms RSV is associated with high rates of hospitalization in infants and sheds light on the burden in the 70+ age group in which a considerable number of deaths was observed, as well as the parallelism with other countries, which is consistent with a wide underdiagnoses issue.
呼吸道合胞病毒（RSV）是导致婴儿和幼儿急性下呼吸道感染的已知原因。本研究旨在分析 2007 年至 2021 年期间威尼托地区（意大利）与 RSV 相关的住院治疗的时间趋势和特征。该分析基于公共和认证私立医院的所有医院出院记录（HDR）进行，这些 HDR 对应于威尼托地区（意大利）发生的住院治疗。如果 HDR 至少包含以下 ICD9-CM 代码之一，则将其视为有效记录：079.6-呼吸道合胞病毒（RSV）；466.11-RSV 引起的急性细支气管炎；480.1-RSV 引起的肺炎。评估了总年度病例数、性别和年龄特异性发病率和趋势。总体而言，2007 年至 2019 年期间，因 RSV 导致的住院人数呈上升趋势，2013-2014 年和 2014-2015 年 RSV 季节略有下降。2020 年 3 月至 2021 年 9 月，几乎没有住院记录，但在 2021 年最后一个季度，住院人数达到了该系列的最高值。我们的数据证实 RSV 住院主要发生在婴儿和幼儿中，RSV 住院具有季节性，急性细支气管炎是最常见的诊断。有趣的是，数据还显示，在年龄较大的成年人中，疾病负担也很大，而且死亡人数也不容忽视。本研究证实 RSV 与婴儿的高住院率有关，并揭示了 70 岁以上人群的负担，其中观察到相当数量的死亡，这与其他国家的情况一致，这与广泛的漏诊问题一致。
