School of Food Science and Engineering, South China University of Technology, Guangzhou 510641, China.
Institute of Food Safety and Nutrition, Jinan University, Guangzhou 510632, China.
Int J Mol Sci. 2023 Feb 28;24(5):4678. doi: 10.3390/ijms24054678.
We explored the antimicrobial activity of sertraline on and further investigated the effects of sertraline on biofilm formation and the virulence gene expression of . The minimum inhibitory concentration and minimum bactericidal concentration for sertraline against were in the range of 16-32 μg/mL and 64 μg/mL, respectively. Sertraline-dependent damage of the cell membrane and a decrease in intracellular ATP and pH in were observed. In addition, sertraline reduced the biofilm formation efficiency of the strains. Importantly, low concentrations (0.1 μg/mL and 1 μg/mL) of sertraline significantly down-regulated the expression levels of various virulence genes (, , , , , and ). These results collectively suggest a role of sertraline for the control of in the food industry.
我们研究了舍曲林对 的抗菌活性，并进一步研究了舍曲林对生物膜形成和 毒力基因表达的影响。舍曲林对 的最小抑菌浓度和最小杀菌浓度范围分别为 16-32μg/mL 和 64μg/mL。观察到舍曲林对 细胞膜的损伤以及细胞内 ATP 和 pH 值的降低。此外，舍曲林降低了 菌株的生物膜形成效率。重要的是，低浓度（0.1μg/mL 和 1μg/mL）的舍曲林显著下调了各种 毒力基因（ 、 、 、 、 、 和 ）的表达水平。这些结果共同表明舍曲林在食品工业中控制 的作用。
