Tran Van N, Lee Hyoung Shin, Truong Van G, Rhee Yun-Hee, Kang Hyun Wook
Department of Biomedical Engineering, Pukyong National University, Busan, South Korea.
Department of Otolaryngology Head and Neck Surgery, Kosin University, Busan, South Korea.
J Biophotonics. 2018 Jan;11(1). doi: 10.1002/jbio.201700073. Epub 2017 Oct 5.
A basket-integrated optical device is developed to consistently treat tubular tissue by centering an optical diffuser in the lumen. Four nitinol arms in conjunction with the optical diffusing applicator are deployed to induce homogeneous circumferential light emission and concentric photothermal coagulation on tracheal tissue. A 1470-nm laser light is employed for the tissue testing at various irradiation conditions and evaluated in terms of thermal gradient and temperature evolution. Preliminary experiments on liver tissue demonstrate the concentric development of the radial thermal coagulation in the tissue (eccentric ratio = ~5.5%). The interstitial tissue temperature increases with the total amount of energy delivery (around 65°C). Ex vivo trachea testing yields up to 16.5% tissue shrinkage due to dehydration as well as uniform ablation of the cilia and goblet cells in a mucosa layer under 7-W irradiation for 10 s. The proposed optical device may be a feasible therapeutic method to entail the circumferential coagulation in the tubular tissues in a reliable manner.
一种集成在篮子里的光学装置被开发出来，通过将光扩散器置于管腔内来持续治疗管状组织。四个镍钛诺臂与光扩散施加器配合使用，以在气管组织上诱导均匀的圆周光发射和同心光热凝固。使用1470纳米的激光在各种照射条件下对组织进行测试，并根据热梯度和温度变化进行评估。对肝脏组织的初步实验表明，组织中径向热凝固呈同心发展（偏心率约为5.5%）。间质组织温度随能量传递总量升高（约65°C）。体外气管测试显示，在7瓦照射10秒的情况下，由于脱水，组织收缩率高达16.5%，同时粘膜层中的纤毛和杯状细胞被均匀消融。所提出的光学装置可能是一种可行的治疗方法，能够以可靠的方式在管状组织中进行圆周凝固。
