Department of Food Science and Nutrition, Pusan National University, Busan 46241, Republic of Korea.
Department of Food Science and Nutrition, Gyeongsang National University, Jinju 52725, Republic of Korea.
Int J Mol Sci. 2023 Mar 2;24(5):4838. doi: 10.3390/ijms24054838.
Alzheimer's disease (AD) is a neurodegenerative disease, associated with progressive cognitive impairment and memory loss. In the present study, we examined the protective effects of paeoniflorin against memory loss and cognitive decline in lipopolysaccharide (LPS)-induced mice. Treatment with paeoniflorin alleviated LPS-induced neurobehavioral dysfunction, as confirmed by behavioral tests, including the T-maze test, novel-object recognition test, and Morris water maze test. LPS stimulated the amyloidogenic pathway-related proteins (amyloid precursor protein, APP; β-site APP cleavage enzyme, BACE; presenilin1, PS1; presenilin2, PS2) expression in the brain. However, paeoniflorin decreased APP, BACE, PS1, and PS2 protein levels. Therefore, paeoniflorin reverses LPS-induced cognitive impairment via inhibition of the amyloidogenic pathway in mice, which suggests that paeoniflorin may be useful in the prevention of neuroinflammation related to AD.
阿尔茨海默病（AD）是一种神经退行性疾病，与进行性认知障碍和记忆力减退有关。在本研究中，我们研究了芍药苷对脂多糖（LPS）诱导的小鼠记忆力丧失和认知能力下降的保护作用。行为测试，包括 T 迷宫测试、新物体识别测试和 Morris 水迷宫测试，证实芍药苷治疗减轻了 LPS 诱导的神经行为功能障碍。LPS 刺激大脑中淀粉样蛋白形成途径相关蛋白（淀粉样前体蛋白，APP；β 位 APP 裂解酶，BACE；早老素 1，PS1；早老素 2，PS2）的表达。然而，芍药苷降低了 APP、BACE、PS1 和 PS2 蛋白水平。因此，芍药苷通过抑制小鼠淀粉样蛋白形成途径逆转 LPS 诱导的认知障碍，这表明芍药苷可能有助于预防与 AD 相关的神经炎症。
