Eckland D J, Lightman S L
Medical Unit, Charing Cross and Westminster Medical School, Westminster Hospital, London, U.K.
Brain Res. 1987 Sep 22;421(1-2):161-6. doi: 10.1016/0006-8993(87)91286-8.
The control of hypothalamo-hypophyseal neurotensin secretion was studied using a modification of the Worthington-Fink portal sampling technique. Portal concentrations of neurotensin were significantly greater than the concentrations found in peripheral plasma, and HPLC characterisation demonstrated that both portal and peripheral plasma neurotensin were very similar. Two different anaesthetic agents, urethane and althesin, did not differ in the resulting portal concentrations of neurotensin. Electrical stimulation of the median eminence resulted in a very marked increase in portal neurotensin concentration.
采用改良的沃辛顿-芬克门静脉采样技术研究下丘脑-垂体神经降压素的分泌调控。门静脉中神经降压素的浓度显著高于外周血浆中的浓度，高效液相色谱分析表明门静脉和外周血浆中的神经降压素非常相似。两种不同的麻醉剂，乌拉坦和阿法沙龙，在门静脉中神经降压素的最终浓度上没有差异。对正中隆起进行电刺激导致门静脉中神经降压素浓度显著升高。
