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下丘脑 - 垂体血流:垂体功能中的一种新型控制机制?

Hypothalamo-hypophysial blood flow: a novel control mechanism in pituitary function?

作者信息

Eckland D J, Lightman S L

出版信息

J Endocrinol. 1987 Apr;113(1):R1-2. doi: 10.1677/joe.0.113r001.

DOI:10.1677/joe.0.113r001
PMID:3585218
Abstract

The flow rate of portal plasma was measured during hypothalamo-hypophysial portal sampling in the rat using a modified Worthington-Fink technique. In rats rendered hypothyroid with propylthiouracil, there was a significant 140% increase in portal plasma flow. Median eminence stimulation also increased portal plasma flow by 41%. Orchidectomy and adrenalectomy had no effects on plasma flow. Modification of flow rate in the hypothalamo-hypophysial vascular bed may represent a further mechanism involved in the control of pituitary function.

摘要

采用改良的沃辛顿-芬克技术,在大鼠下丘脑-垂体门脉采样期间测量门脉血浆流速。在用丙硫氧嘧啶使大鼠甲状腺功能减退后,门脉血浆流速显著增加了140%。正中隆起刺激也使门脉血浆流速增加了41%。睾丸切除术和肾上腺切除术对血浆流速无影响。下丘脑-垂体血管床流速的改变可能是参与垂体功能调控的另一种机制。

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1
Hypothalamo-hypophysial blood flow: a novel control mechanism in pituitary function?下丘脑 - 垂体血流:垂体功能中的一种新型控制机制?
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引用本文的文献

1
Vascularity in Nontumorous Human Pituitaries and Incidental Microadenomas: A Morphometric Study.非肿瘤性人类垂体及意外发现的微腺瘤的血管分布:一项形态计量学研究。
Endocr Pathol. 2000 Autumn;11(3):215-227. doi: 10.1385/ep:11:3:215.
2
Hypothalamo-hypophyseal portal blood sampling from laboratory rats. The effects of endocrine manipulations on portal blood catecholamine concentrations.
Exp Brain Res. 1988;72(3):640-4. doi: 10.1007/BF00250608.
3
Medium flow rate modulates autocrine-paracrine feedback of GH and PRL release by perifused GH3 cells.中等流速调节经灌流的GH3细胞对生长激素(GH)和催乳素(PRL)释放的自分泌-旁分泌反馈。
In Vitro Cell Dev Biol. 1990 May;26(5):482-92. doi: 10.1007/BF02624090.