Sharma H S, Dey P K
Department of Physiology, Banaras Hindu University, Varanasi, India.
Brain Res. 1987 Oct 20;424(1):153-62. doi: 10.1016/0006-8993(87)91205-4.
Exposure of conscious young rats to 4 h heat stress at 38 degrees C in B.O.D. incubator was associated with increased blood-brain barrier (BBB) permeability in 14 brain regions studied. In the same regions cerebral flow (CBF) diminished by 4-65%, but the magnitude of flow reduction was not correlated with the degree of increased BBB permeability. On the other hand, a correlation was observed with increased plasma and brain 5-hydroxytryptamine (5-HT) levels. p-Chlorophenylalanine (p-CPA), indomethacin and diazepam pretreatment prevented both the increased BBB permeability and 5-HT levels following heat exposure. Whereas cyproheptadine and vinblastine pretreatment prevented the increased BBB permeability alone. The probable mechanism(s) underlying the BBB permeability is discussed.
将清醒的幼鼠置于生化培养箱中38摄氏度环境下热应激4小时，在所研究的14个脑区中，血脑屏障（BBB）通透性增加。在相同区域，脑血流量（CBF）减少了4% - 65%，但血流量减少的幅度与血脑屏障通透性增加的程度无关。另一方面，观察到血脑屏障通透性增加与血浆和脑内5-羟色胺（5-HT）水平升高相关。对氯苯丙氨酸（p-CPA）、吲哚美辛和地西泮预处理可防止热暴露后血脑屏障通透性增加和5-HT水平升高。而赛庚啶和长春碱预处理仅能防止血脑屏障通透性增加。文中讨论了血脑屏障通透性增加的可能机制。
