Sharma H S, Dey P K
J Neurol Sci. 1986 Jan;72(1):61-76. doi: 10.1016/0022-510x(86)90036-5.
Eight hours immobilization stress in young rats has increased the blood-brain barrier (BBB) permeability in 12 out of 14 brain regions studied. In the same regions cerebral blood flow (CBF) diminished by 2-37%, but the magnitude of flow reduction was not correlated with the degree of increased BBB permeability. On the other hand, a correlation was observed with increased plasma and brain 5-HT levels. The increased BBB permeability and increased 5-HT levels were prevented by pretreatment with p-CPA, indomethacin and diazepam. Cyproheptadine and vinblastine pretreatment prevented the occurrence of increased BBB permeability alone. The probable mechanism(s) underlying the breakdown of BBB permeability is discussed.
对幼鼠施加8小时的固定应激后，在所研究的14个脑区中的12个脑区，血脑屏障（BBB）通透性增加。在相同区域，脑血流量（CBF）减少了2% - 37%，但血流量减少的幅度与血脑屏障通透性增加的程度无关。另一方面，观察到血脑屏障通透性增加与血浆和脑内5-羟色胺（5-HT）水平升高相关。对氯苯丙氨酸（p-CPA）、吲哚美辛和地西泮预处理可防止血脑屏障通透性增加和5-HT水平升高。赛庚啶和长春碱预处理仅能防止血脑屏障通透性增加的发生。文中讨论了血脑屏障通透性破坏的可能机制。
