Inase M, Nakahama H, Otsuki T, Fang J Z
Division of Neurophysiology, Tohoku University School of Medicine, Sendai, Japan.
Brain Res. 1987 Nov 24;426(2):205-11. doi: 10.1016/0006-8993(87)90874-2.
The effects of 5-hydroxytryptamine (5-HT) microinjection into the nucleus raphe magnus (NRM) and the nucleus raphe dorsalis (NRD) on tonic pain were studied using the monosodium urate (MSU) tonic pain model in the rat. For the NRM, 5-HT microinjection produced significant analgesic effects, which were antagonized by systemic naloxone administration and also by subsequent microinjection of naloxone into the NRM. For the NRD, systemic naloxone administration did not antagonize these analgesic effects, although 5-HT microinjection produced significant analgesic effects. Therefore, as far as tonic pain is concerned, it was suggested that neural transmission mediated by 5-HT in the NRM and NRD plays an antinociceptive action, but via different neural mechanisms.
利用大鼠尿酸钠（MSU）强直性疼痛模型，研究了向中缝大核（NRM）和中缝背核（NRD）微量注射5-羟色胺（5-HT）对强直性疼痛的影响。对于中缝大核，微量注射5-HT产生显著的镇痛作用，全身给予纳洛酮以及随后向中缝大核微量注射纳洛酮均可拮抗这种作用。对于中缝背核，尽管微量注射5-HT产生显著的镇痛作用，但全身给予纳洛酮并不能拮抗这些镇痛作用。因此，就强直性疼痛而言，提示5-HT在中缝大核和中缝背核介导的神经传递发挥抗伤害感受作用，但通过不同的神经机制。
