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先前未知的 7-芳基取代帕洛酮的有效合成。

An Effective Synthesis of Previously Unknown 7-Aryl Substituted Paullones.

机构信息

Department of Chemistry, North Caucasus Federal University, 1a Pushkin St., 355009 Stavropol, Russia.

出版信息

Molecules. 2023 Mar 2;28(5):2324. doi: 10.3390/molecules28052324.

DOI:10.3390/molecules28052324
PMID:36903571
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10005103/
Abstract

A straightforward three-step procedure affording a wide range of novel 7-aryl substituted paullone derivatives was developed. This scaffold is structurally similar to 2-(1-indol-3-yl)acetamides-promising antitumor agents-hence, could be useful for the development of a new class of anticancer drugs.

摘要

开发了一种直截了当的三步法，可获得广泛的新型 7-芳基取代的 paullone 衍生物。该支架结构与 2-(1-吲哚-3-基)乙酰胺类似，是有前途的抗肿瘤剂-因此，可用于开发一类新的抗癌药物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c59/10005103/89f453b783f6/molecules-28-02324-sch006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c59/10005103/c9b231c0e789/molecules-28-02324-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c59/10005103/cd6661f42c3a/molecules-28-02324-sch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c59/10005103/50e5184dc8a3/molecules-28-02324-sch002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c59/10005103/e2a09f1f5aab/molecules-28-02324-sch003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c59/10005103/78a1ba1972c4/molecules-28-02324-sch004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c59/10005103/c394c8fa046e/molecules-28-02324-sch005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c59/10005103/89f453b783f6/molecules-28-02324-sch006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c59/10005103/c9b231c0e789/molecules-28-02324-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c59/10005103/cd6661f42c3a/molecules-28-02324-sch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c59/10005103/50e5184dc8a3/molecules-28-02324-sch002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c59/10005103/e2a09f1f5aab/molecules-28-02324-sch003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c59/10005103/78a1ba1972c4/molecules-28-02324-sch004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c59/10005103/c394c8fa046e/molecules-28-02324-sch005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c59/10005103/89f453b783f6/molecules-28-02324-sch006.jpg

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本文引用的文献

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J Org Chem. 2022 Nov 4;87(21):13955-13964. doi: 10.1021/acs.joc.2c01627. Epub 2022 Oct 19.
2
Oxidative Cyclization of 4-(2-Aminophenyl)-4-oxo-2-phenylbutanenitriles into 2-(3-Oxoindolin-2-ylidene)acetonitriles.4-(2-氨基苯基)-4-氧代-2-苯基丁腈氧化环化生成2-(3-氧代吲哚啉-2-亚基)乙腈
ACS Omega. 2022 Apr 15;7(16):14345-14356. doi: 10.1021/acsomega.2c01238. eCollection 2022 Apr 26.
3
Synthesis of 2-(1-Indol-2-yl)acetamides via Brønsted Acid-Assisted Cyclization Cascade.
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J Org Chem. 2020 Oct 2;85(19):12128-12146. doi: 10.1021/acs.joc.0c01344. Epub 2020 Sep 16.
4
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Invest New Drugs. 2020 Aug;38(4):977-989. doi: 10.1007/s10637-019-00849-6. Epub 2019 Sep 6.
5
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J Org Chem. 2019 Jun 7;84(11):7123-7137. doi: 10.1021/acs.joc.9b00808. Epub 2019 May 22.
6
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Chem Commun (Camb). 2018 Nov 22;54(94):13260-13263. doi: 10.1039/c8cc07451h.
7
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8
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9
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10
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Chem Asian J. 2016 Dec 6;11(23):3345-3349. doi: 10.1002/asia.201601290. Epub 2016 Nov 7.