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通过绿色化学合成的超顺磁性氧化铁纳米粒子，有望用于治疗乳腺癌。

Superparamagnetic Iron-Oxide Nanoparticles Synthesized via Green Chemistry for the Potential Treatment of Breast Cancer.

机构信息

Department of Pharmaceutics, School of Pharmaceutical Education & Research, Jamia Hamdard, New Delhi 110062, India.

Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, The University of Iowa, Iowa City, IA 52242, USA.

出版信息

Molecules. 2023 Mar 3;28(5):2343. doi: 10.3390/molecules28052343.

DOI:10.3390/molecules28052343
PMID:36903587
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10005561/
Abstract

In the emerging field of nanomedicine, nanoparticles have been widely considered as drug carriers and are now used in various clinically approved products. Therefore, in this study, we synthesized superparamagnetic iron-oxide nanoparticles (SPIONs) via green chemistry, and the SPIONs were further coated with tamoxifen-conjugated bovine serum albumin (BSA-SPIONs-TMX). The BSA-SPIONs-TMX were within the nanometric hydrodynamic size (117 ± 4 nm), with a small poly dispersity index (0.28 ± 0.02) and zeta potential of -30.2 ± 0.09 mV. FTIR, DSC, X-RD, and elemental analysis confirmed that BSA-SPIONs-TMX were successfully prepared. The saturation magnetization (M) of BSA-SPIONs-TMX was found to be ~8.31 emu/g, indicating that BSA-SPIONs-TMX possess superparamagnetic properties for theragnostic applications. In addition, BSA-SPIONs-TMX were efficiently internalized into breast cancer cell lines (MCF-7 and T47D) and were effective in reducing cell proliferation of breast cancer cells, with IC values of 4.97 ± 0.42 μM and 6.29 ± 0.21 μM in MCF-7 and T47D cells, respectively. Furthermore, an acute toxicity study on rats confirmed that these BSA-SPIONs-TMX are safe for use in drug delivery systems. In conclusion, green synthesized superparamagnetic iron-oxide nanoparticles have the potential to be used as drug delivery carriers and may also have diagnostic applications.

摘要

在新兴的纳米医学领域，纳米粒子已被广泛认为是药物载体，目前已应用于各种临床批准的产品中。因此，在本研究中，我们通过绿色化学合成了超顺磁性氧化铁纳米粒子（SPIONs），并进一步将其包覆于与他莫昔芬偶联的牛血清白蛋白（BSA-SPIONs-TMX）上。BSA-SPIONs-TMX 的纳米级水动力粒径（117 ± 4nm）较小，多分散指数（PDI）为 0.28 ± 0.02，zeta 电位为-30.2 ± 0.09mV。傅里叶变换红外光谱（FTIR）、差示扫描量热法（DSC）、X 射线衍射（XRD）和元素分析证实了 BSA-SPIONs-TMX 的成功制备。BSA-SPIONs-TMX 的饱和磁化强度（M）约为 8.31 emu/g，表明 BSA-SPIONs-TMX 具有超顺磁性，可用于诊断和治疗应用。此外，BSA-SPIONs-TMX 能够有效地被乳腺癌细胞系（MCF-7 和 T47D）内化，并有效抑制乳腺癌细胞的增殖，在 MCF-7 和 T47D 细胞中的 IC 值分别为 4.97 ± 0.42μM 和 6.29 ± 0.21μM。此外，大鼠急性毒性研究证实，这些 BSA-SPIONs-TMX 用于药物递送系统是安全的。总之，绿色合成的超顺磁性氧化铁纳米粒子有望作为药物载体使用，并且可能具有诊断应用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa16/10005561/fc1b9a6ebda3/molecules-28-02343-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa16/10005561/066fa507379c/molecules-28-02343-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa16/10005561/b1f4ce625d18/molecules-28-02343-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa16/10005561/5593078acbab/molecules-28-02343-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa16/10005561/8b764a332636/molecules-28-02343-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa16/10005561/6fcfafcc8ab3/molecules-28-02343-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa16/10005561/ee31a4b9ea25/molecules-28-02343-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa16/10005561/96aa685faabc/molecules-28-02343-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa16/10005561/3d9626426a2d/molecules-28-02343-g008a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa16/10005561/fae068e94af7/molecules-28-02343-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa16/10005561/fc1b9a6ebda3/molecules-28-02343-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa16/10005561/066fa507379c/molecules-28-02343-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa16/10005561/b1f4ce625d18/molecules-28-02343-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa16/10005561/5593078acbab/molecules-28-02343-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa16/10005561/8b764a332636/molecules-28-02343-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa16/10005561/6fcfafcc8ab3/molecules-28-02343-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa16/10005561/ee31a4b9ea25/molecules-28-02343-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa16/10005561/96aa685faabc/molecules-28-02343-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa16/10005561/3d9626426a2d/molecules-28-02343-g008a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa16/10005561/fae068e94af7/molecules-28-02343-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa16/10005561/fc1b9a6ebda3/molecules-28-02343-g010.jpg

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本文引用的文献

[1]
Role of Iron Oxide (FeO) Nanocomposites in Advanced Biomedical Applications: A State-of-the-Art Review.

Nanomaterials (Basel). 2022-11-2

[2]
Folic acid engineered sulforaphane loaded microbeads for targeting breast cancer.

J Biomater Sci Polym Ed. 2023-4

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Smart and Multi-Functional Magnetic Nanoparticles for Cancer Treatment Applications: Clinical Challenges and Future Prospects.

Nanomaterials (Basel). 2022-10-12

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Nanostructured Lipid Carrier-Based Codelivery of Raloxifene and Naringin: Formulation, Optimization, In Vitro, Ex Vivo, In Vivo Assessment, and Acute Toxicity Studies.

Pharmaceutics. 2022-8-25

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Combinatorial Chemosensitive Nanomedicine Approach for the Treatment of Breast Cancer.

Curr Mol Med. 2023

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Polymeric Composite of Magnetite Iron Oxide Nanoparticles and Their Application in Biomedicine: A Review.

Polymers (Basel). 2022-2-15

[9]
Recent advances in targeted nanotherapeutic approaches for breast cancer management.

Nanomedicine (Lond). 2021-12

[10]
The Uniqueness of Albumin as a Carrier in Nanodrug Delivery.

Mol Pharm. 2021-5-3

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