Sharma Ritu, Basist Parakh, Alhalmi Abdulsalam, Khan Rahmuddin, Noman Omar M, Alahdab Ahmad
School of Medical and Allied Sciences, K.R. Mangalam University, Gurugram 122103, India.
Department of Pharmacology, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi 110062, India.
Micromachines (Basel). 2023 Nov 25;14(12):2154. doi: 10.3390/mi14122154.
The study delves into the multifaceted potential of quercetin (Qu), a phytoconstituent found in various fruits, vegetables, and medicinal plants, in combination with silver nanoparticles (AgNPs). The research explores the synthesis and characterization of AgNPs loaded with Qu and investigates their pharmaceutical applications, particularly focusing on antibacterial properties. The study meticulously evaluates Qu's identity, and physicochemical properties, reaffirming its suitability for pharmaceutical use. The development of Qu-loaded AgNPs demonstrates their high drug entrapment efficiency, ideal particle characteristics, and controlled drug release kinetics, suggesting enhanced therapeutic efficacy and reduced side effects. Furthermore, the research examines the antibacterial activity of Qu in different solvents, revealing distinct outcomes. Qu, both in methanol and water formulations, exhibits antibacterial activity against , with the methanol formulation displaying a slightly stronger efficacy. In conclusion, this study successfully synthesizes AgNPs loaded with Qu and highlights their potential as a potent antibacterial formulation. The findings underscore the influence of solvent choice on Qu's antibacterial properties and pave the way for further research and development in drug delivery systems and antimicrobial agents. This innovative approach holds promise for addressing microbial resistance and advancing pharmaceutical formulations for improved therapeutic outcomes.
该研究深入探讨了槲皮素（Qu）与银纳米颗粒（AgNPs）结合的多方面潜力，槲皮素是一种存在于各种水果、蔬菜和药用植物中的植物成分。该研究探索了负载槲皮素的银纳米颗粒的合成与表征，并研究了它们的药物应用，尤其侧重于抗菌特性。该研究细致地评估了槲皮素的特性和物理化学性质，再次确认了其适用于药物用途。负载槲皮素的银纳米颗粒的研发展示了它们高的药物包封效率、理想的颗粒特性和可控的药物释放动力学，表明其治疗效果增强且副作用减少。此外，该研究考察了槲皮素在不同溶剂中的抗菌活性，揭示了不同的结果。槲皮素在甲醇和水制剂中均对……表现出抗菌活性，其中甲醇制剂的疗效略强。总之，该研究成功合成了负载槲皮素的银纳米颗粒，并突出了它们作为一种强效抗菌制剂的潜力。这些发现强调了溶剂选择对槲皮素抗菌特性的影响，并为药物递送系统和抗菌剂的进一步研发铺平了道路。这种创新方法有望解决微生物耐药性问题，并推动药物制剂的发展以改善治疗效果。
