McKee R H, Lewis S C
Exxon Biomedical Sciences, Inc., East Millstone, NJ 08873.
Can J Physiol Pharmacol. 1987 Aug;65(8):1793-7. doi: 10.1139/y87-279.
This study assessed the dermal carcinogenic potential of raw bitumen derived from the Cold Lake Oil Sands deposit (located in Northeast Alberta, Canada) and two liquids which were under evaluation as part of a process to refine the crude bitumen at the Cold Lake site. The crude bitumen was dermally carcinogenic, inducing tumors in 26% of the treated animals with a median latency of 106 weeks. This response was significantly greater than the tumor yield previously reported for a raw bitumen derived from Athabasca tar sands by the Syncrude process, but was not substantially different from the carcinogenic potential of two crude petroleum oils. The GO-FINING product, a high boiling (259-519 degrees C), catalytically cracked gas oil was a relatively potent dermal carcinogen, inducing tumors in 86% of the treated animals with a median latency of 46 weeks. This result is consistent with the fact that the GO-FINING product contained appreciable levels of high boiling aromatic compounds. The HYCRACKING product, a high boiling (102-498 degrees C), severely hydroprocessed liquid was noncarcinogenic. This result was also consistent with the compositional data; the high boiling components were predominantly saturated species. Thus the carcinogenic properties of the liquid products prepared by these two processes were as predicted from the compositional information.
本研究评估了源自加拿大阿尔伯塔省东北部冷湖油砂矿床的原沥青以及作为冷湖地区原油沥青精炼工艺一部分正在评估的两种液体的皮肤致癌潜力。原沥青具有皮肤致癌性，在26%的受试动物中诱发肿瘤，中位潜伏期为106周。这一反应显著高于之前Syncrude工艺报道的源自阿萨巴斯卡油砂的原沥青的肿瘤发生率，但与两种原油的致癌潜力没有实质性差异。GO - FINING产品是一种高沸点（259 - 519摄氏度）的催化裂化瓦斯油，是一种相对强效的皮肤致癌物，在86%的受试动物中诱发肿瘤，中位潜伏期为46周。这一结果与GO - FINING产品含有相当水平的高沸点芳香族化合物这一事实相符。HYCRACKING产品是一种高沸点（102 - 498摄氏度）的深度加氢处理液体，无致癌性。这一结果也与成分数据一致；高沸点成分主要是饱和物种。因此，这两种工艺制备的液体产品的致癌特性与成分信息预测的一致。
