McKee R H, Plutnick R T
Exxon Biomedical Sciences, Inc., East Millstone, NJ 08875-2350, USA.
J Appl Toxicol. 1995 Mar-Apr;15(2):85-90. doi: 10.1002/jat.2550150205.
A series of liquids representing different potential design options or operating configurations for the EDS direct coal liquefaction process* were evaluated for skin cancer potential. All of the samples that contained substantial amounts of material boiling above 370 degrees C were active dermal carcinogens; tumor yields were near 100% and median times to tumor development generally ranged from 30 to 40 weeks. Two liquids that boiled below ca. 200 degrees C were tested and each produced one squamous cell tumor. These data suggested that high-boiling-point, coal-derived liquids are likely to be relatively potent dermal carcinogens; whereas low-boiling-point liquids do not possess significant carcinogenic potential. Based on a comparison of the carcinogenic potency data, liquids produced by the EDS process apparently do not present a significantly greater dermal carcinogenic hazard than other coal-derived materials of similar boiling range.
对一系列代表能源部直接煤炭液化工艺*不同潜在设计方案或操作配置的液体进行了皮肤癌潜在风险评估。所有含有大量沸点高于370摄氏度物质的样品都是活性皮肤致癌物；肿瘤发生率接近100%，肿瘤发生的中位时间通常在30至40周之间。测试了两种沸点低于约200摄氏度的液体，每种液体都产生了一个鳞状细胞瘤。这些数据表明，高沸点的煤炭衍生液体可能是相对强效的皮肤致癌物；而低沸点液体没有显著的致癌潜力。根据致癌效力数据的比较，能源部工艺生产的液体显然不会比其他类似沸点范围的煤炭衍生材料带来显著更高的皮肤致癌风险。
