Farnworth E R, Kramer J K
Animal Research Centre, Agriculture Canada, Ottawa, Ont.
Can J Physiol Pharmacol. 1987 Sep;65(9):1872-7. doi: 10.1139/y87-290.
Weanling male rats were fed diets containing 5, 10, or 20% (by weight) fat. Diets were made isocaloric by decreasing the amount of starch as the diet fat level increased. At each fat level, three oil mixtures were fed which contained 13, 32, or 79% saturated fatty acids. The polyunsaturate level was 11% of total fatty acids in all mixtures. After 12 weeks, animals eating the high fat diets had gained significantly less weight and had eaten less feed. These animals also had significantly lighter livers and more liver lipids. The level and type of fat in the diet affected the amount (mg/g) of several phospholipids in the liver and heart. The fatty acid patterns (total saturates, n - 3, n - 6 fatty acids) of the major phospholipids were generally constant, the monounsaturated fatty acids being the major exception.
断奶雄性大鼠被喂食含有5%、10%或20%（按重量计）脂肪的饮食。随着饮食中脂肪水平的增加，通过减少淀粉量使饮食达到等热量。在每个脂肪水平下，喂食三种油混合物，其饱和脂肪酸含量分别为13%、32%或79%。所有混合物中多不饱和脂肪酸水平占总脂肪酸的11%。12周后，食用高脂肪饮食的动物体重增加明显较少，进食量也较少。这些动物的肝脏也明显更轻，肝脏脂质更多。饮食中脂肪的水平和类型影响肝脏和心脏中几种磷脂的含量（毫克/克）。主要磷脂的脂肪酸模式（总饱和脂肪酸、n - 3、n - 6脂肪酸）通常是恒定的，单不饱和脂肪酸是主要例外。
