Jones P J, Toy B R, Cha M C
Division of Human Nutrition, University of British Columbia, Vancouver, Canada.
J Nutr. 1995 May;125(5):1175-82. doi: 10.1093/jn/125.5.1175.
To examine interactive effects of dietary fatty acid composition and energy restriction on tissue fatty acid accretion, mature rats consumed diets containing beef tallow, fish oil, olive oil or safflower oil with free access or at 85% or 68% of free access energy intakes. Restriction was accomplished by adjustment of dietary carbohydrate level. After 10 wk, animals were killed, and the fatty acid compositions of liver, heart and adipose tissues were examined. Compared with animals given free access to diets, body weight gains were reduced at wk 10 in fish oil- and olive oil-fed groups consuming 85% (P < 0.01) and in all groups consuming 68% (P < 0.005) of free access energy intake. Liver and heart weights were also lower (P < 0.05) in all groups restricted to 68% of free access energy intake. The type of dietary fat and the level of energy restriction influenced fatty acid composition in all three tissues at wk 10. In liver tissue, graded energy restriction increased (P < 0.02) proportions of stearic acid and decreased (P < 0.03) those of palmitic acid. In heart tissue, palmitic acid levels decreased (P < 0.01) with energy restriction. In adipose tissue, significant energy restriction-related changes in fatty acid composition varied with type of fat consumed. These results emphasize the importance of whole-body energy balance in addition to dietary fatty acid supply in utilization of dietary fatty acids for tissue deposition vs. oxidation.
为研究膳食脂肪酸组成与能量限制对组织脂肪酸蓄积的交互作用，成年大鼠分别食用含牛脂、鱼油、橄榄油或红花油的日粮，可自由采食，或采食自由采食量85%或68%的日粮。通过调整膳食碳水化合物水平来实现能量限制。10周后，处死动物，检测肝脏、心脏和脂肪组织的脂肪酸组成。与自由采食日粮的动物相比，采食自由采食量85%的鱼油和橄榄油喂养组在第10周时体重增加减少（P<0.01），而采食自由采食量68%的所有组体重增加均减少（P<0.005）。采食自由采食量68%的所有组肝脏和心脏重量也较低（P<0.05）。日粮脂肪类型和能量限制水平在第10周时影响所有三种组织的脂肪酸组成。在肝脏组织中，分级能量限制使硬脂酸比例增加（P<0.02），棕榈酸比例降低（P<0.03）。在心脏组织中，能量限制使棕榈酸水平降低（P<0.01）。在脂肪组织中，与能量限制相关的脂肪酸组成显著变化因所摄入脂肪类型而异。这些结果强调了在膳食脂肪酸用于组织沉积与氧化的过程中，除膳食脂肪酸供应外，全身能量平衡的重要性。
