Kramer J K, Hulan H W, Trenholm H L, Corner A H
J Nutr. 1979 Feb;109(2):202-13. doi: 10.1093/jn/109.2.202.
Studies were carried out on Sprague-Dawley (SD) and Chester Beatty (CB) rats to determine whether the difference in incidence of myocardial lesions can be related to dietary factors and parameters known to be affected in SD rats fed rapeseed oils. The two strains of young, male rats were fed diets which contained 20% by weight of either corn, LEAR (low erucic acid) or HEAR (high erucic acid rapeseed) oils for a period of up to 16 weeks. A significantly lower incidence of focal myocardial necrosis was observed in CB rats than in SD rats. The incidence of this heart lesion in CB rats was similar between all diets; in SD rats a higher incidence was observed in the groups fed rapeseed oils. In both strains the growth rates of rats fed LEAR and corn oils were similar; growth rates with HEAR oil diets were much lower than the other oils. Severe myocardial lipidosis was only evident in rats fed HEAR oil, but no strain differences were observed. The pattern and extent of lipidosis, including cardiac and hepatic lipid levels and fatty acid compositions, were similar in both strains at the time periods studied. Cardiac triglycerides and free fatty acids increased in rats fed HEAR oil, but no strain differences were evident. Strain differences were found in the levels of a few cardiac phospholipids of rats fed HEAR oil, however, the relative fatty acid compositions of each phospholipid were remarkably similar. Microscopic examination of the livers showed no evidence that feeding rapeseed oil caused any specific effect which could be related to differences in heart lesion response. There was no evidence to indicate that differences in heart lesion response between the two rat strains could be related to cardiac triglycerides, free fatty acids or phospholipids.
对斯普拉格-道利（SD）大鼠和切斯特·比蒂（CB）大鼠进行了研究，以确定心肌损伤发生率的差异是否与饮食因素以及已知在喂食菜籽油的SD大鼠中受到影响的参数有关。将这两种年轻雄性大鼠品系喂食含有20%（按重量计）玉米油、低芥酸菜籽油（LEAR）或高芥酸菜籽油（HEAR）的饮食，为期长达16周。观察到CB大鼠局灶性心肌坏死的发生率明显低于SD大鼠。CB大鼠中这种心脏病变的发生率在所有饮食之间相似；在SD大鼠中，喂食菜籽油的组中观察到更高的发生率。在两个品系中，喂食LEAR油和玉米油的大鼠生长速率相似；喂食HEAR油饮食的大鼠生长速率远低于其他油类。严重的心肌脂肪变性仅在喂食HEAR油的大鼠中明显，但未观察到品系差异。在所研究的时间段内，两个品系的脂肪变性模式和程度，包括心脏和肝脏脂质水平以及脂肪酸组成相似。喂食HEAR油的大鼠心脏甘油三酯和游离脂肪酸增加，但品系差异不明显。然而，在喂食HEAR油的大鼠的一些心脏磷脂水平上发现了品系差异，不过每种磷脂的相对脂肪酸组成非常相似。肝脏的显微镜检查没有证据表明喂食菜籽油会产生任何与心脏病变反应差异相关的特定影响。没有证据表明这两种大鼠品系之间心脏病变反应的差异与心脏甘油三酯、游离脂肪酸或磷脂有关。
