Fundación Renal Íñigo Álvarez de Toledo, 28003 Madrid, Spain.
Servicio de Nefrología e Hipertensión, Fundación Jiménez Díaz, 28040 Madrid, Spain.
Nutrients. 2023 Feb 23;15(5):1115. doi: 10.3390/nu15051115.
(1) Background: Persons with chronic kidney disease may have sarcopenia characterized by the loss of muscle mass and loss of muscle strength. However, EWGSOP2 criteria to diagnose sarcopenia are technically challenging, especially in elderly persons on hemodialysis. Sarcopenia may be associated with malnutrition. We aimed at defining a sarcopenia index derived from malnutrition parameters for use in elderly haemodialysis patients. (2) Methods: A retrospective study of 60 patients aged 75 to 95 years treated with chronic hemodialysis was conducted. Anthropometric and analytical variables, EWGSOP2 sarcopenia criteria and other nutrition-related variables were collected. Binomial logistic regressions were used to define the combination of anthropometric and nutritional parameters that best predict moderate or severe sarcopenia according to EWGSOP2, and performance for moderate and severe sarcopenia was assessed by the area under the curve (AUC) of receiver operating characteristic (ROC) curves. (3) Results: The combination of loss of strength, loss of muscle mass and low physical performance correlated with malnutrition. We developed regression-equation-related nutrition criteria that predicted moderate sarcopenia (elderly hemodialysis sarcopenia index-moderate, EHSI-M) and severe sarcopenia (EHSI-S) diagnosed according to EWGSOP2 with an AUC of 0.80 and 0.866, respectively. (4) Conclusions: There is a close relationship between nutrition and sarcopenia. The EHSI may identify EWGSOP2-diagnosed sarcopenia from easily accessible anthropometric and nutritional parameters.
(1) 背景:患有慢性肾病的患者可能患有以肌肉质量减少和肌肉力量丧失为特征的肌少症。然而,诊断肌少症的 EWGSOP2 标准在技术上具有挑战性,尤其是在老年血液透析患者中。肌少症可能与营养不良有关。我们旨在定义一种源自营养不良参数的肌少症指数,用于老年血液透析患者。(2) 方法:对 60 名年龄在 75 至 95 岁之间接受慢性血液透析治疗的患者进行了回顾性研究。收集了人体测量和分析变量、EWGSOP2 肌少症标准以及其他与营养相关的变量。使用二项逻辑回归来定义根据 EWGSOP2 最佳预测中度或重度肌少症的人体测量和营养参数的组合,并通过接受者操作特征 (ROC) 曲线的曲线下面积 (AUC) 评估中度和重度肌少症的性能。(3) 结果:力量丧失、肌肉质量减少和身体机能低下的组合与营养不良相关。我们制定了回归方程相关的营养标准,可预测根据 EWGSOP2 诊断的中度肌少症(老年血液透析肌少症指数-中度,EHSI-M)和重度肌少症(EHSI-S),AUC 分别为 0.80 和 0.866。(4) 结论:营养与肌少症之间存在密切关系。EHSI 可以根据易于获得的人体测量和营养参数来识别根据 EWGSOP2 诊断的肌少症。