Center for Composite Materials, Harbin Institute of Technology, Harbin 150001, China.
School of Physics, Harbin Institute of Technology, Harbin 150001, China.
Sensors (Basel). 2023 Feb 23;23(5):2478. doi: 10.3390/s23052478.
Monitoring the properties of fluids in microfluidic chips often requires complex open-space optics technology and expensive equipment. In this work, we introduce dual-parameter optical sensors with fiber tips into the microfluidic chip. Multiple sensors were distributed in each channel of the chip, which enabled the real-time monitoring of the concentration and temperature of the microfluidics. The temperature sensitivity and glucose concentration sensitivity could reach 314 pm/°C and -0.678 dB/(g/L), respectively. The hemispherical probe hardly affected the microfluidic flow field. The integrated technology combined the optical fiber sensor with the microfluidic chip and was low cost with high performance. Therefore, we believe that the proposed microfluidic chip integrated with the optical sensor is beneficial for drug discovery, pathological research and material science investigation. The integrated technology has great application potential for micro total analysis systems (μ-TAS).
在微流控芯片中监测流体的性质通常需要复杂的开放空间光学技术和昂贵的设备。在这项工作中，我们将带有光纤尖端的双参数光学传感器引入微流控芯片中。多个传感器分布在芯片的每个通道中，实现了对微流体浓度和温度的实时监测。温度灵敏度和葡萄糖浓度灵敏度分别达到 314 pm/°C 和-0.678 dB/（g/L）。半球形探头几乎不会影响微流场。光纤传感器与微流控芯片的集成技术具有低成本、高性能的特点。因此，我们相信，与光学传感器集成的微流控芯片有利于药物发现、病理研究和材料科学研究。该集成技术在微全分析系统（μ-TAS）中有很大的应用潜力。
