Inspection Department, Qinhuangdao Central Blood Station, Qinhuangdao, 066000, China.
Cell Mol Biol (Noisy-le-grand). 2022 Sep 30;68(9):109-112. doi: 10.14715/cmb/2022.68.9.17.
This experiment was designed to explore the changes in serum Se selectin, ACTH, LPS and SIRT1 levels in patients with acute pancreatitis and their correlation with the severity of the disease. To do this research, from March 2019 to December 2020, 86 patients with different degrees of acute pancreatitis were selected as the research object. They were divided into mild acute pancreatitis (MAP) group (n = 43), moderately severe acute pancreatitis and severe acute pancreatitis (MSAP + SAP) group (n = 43) and healthy group (n = 43). At the same time, the serum levels of Se selectin, ACTH, LPS and SIRT1 were detected after hospitalization. Results showed that the levels of serum Se selectin, ACTH and SIRT1 in the MAP group and MSAP + SAP group were lower than those in the healthy group; The LPS of the MAP group and MSAP + SAP group were higher than that of the healthy group. The results showed that serum Se selectin, ACTH and SIRT1 decreased with the development of the disease, showing a negative correlation; The change of LPS in patients will increase with the development of the disease, showing a positive correlation. Serum Se selectin, ACTH, SIRT1, and LPS can be used as diagnostic criteria and indicators of acute pancreatitis to achieve early prevention and treatment and improve the prognosis and quality of life of patients.
本实验旨在探讨急性胰腺炎患者血清 Se 选择素、ACTH、LPS 和 SIRT1 水平的变化及其与疾病严重程度的相关性。为此，研究人员于 2019 年 3 月至 2020 年 12 月选取了 86 例不同程度的急性胰腺炎患者作为研究对象，将其分为轻症急性胰腺炎（MAP）组（n=43）、中重症急性胰腺炎和重症急性胰腺炎（MSAP+SAP）组（n=43）和健康组（n=43）。同时，在入院后检测了血清 Se 选择素、ACTH、LPS 和 SIRT1 水平。结果显示，MAP 组和 MSAP+SAP 组血清 Se 选择素、ACTH 和 SIRT1 水平均低于健康组，而 MAP 组和 MSAP+SAP 组 LPS 水平均高于健康组。结果表明，血清 Se 选择素、ACTH 和 SIRT1 随着疾病的发展而降低，呈负相关；患者 LPS 的变化会随着疾病的发展而增加，呈正相关。血清 Se 选择素、ACTH、SIRT1 和 LPS 可作为急性胰腺炎的诊断标准和指标，以实现早期预防和治疗，改善患者的预后和生活质量。
