Université de Bordeaux, CNRS, ImmunoConcEpT, UMR 5164, Bordeaux, France.
UMR CNRS 5164 - Immunoconcept, Université de Bordeaux, Bordeaux, France.
Methods Mol Biol. 2023;2618:3-16. doi: 10.1007/978-1-0716-2938-3_1.
Dendritic cells are cells of hematopoietic origin that are specialized in antigen presentation and instruction of innate and adaptive immune responses. They are a heterogenous group of cells populating lymphoid organs and most tissues. Dendritic cells are commonly separated in three main subsets that differ in their developmental paths, phenotype, and functions. Most studies on dendritic cells were done primarily in mice; therefore, in this chapter, we propose to summarize the current knowledge and recent progress on mouse dendritic cell subsets' development, phenotype, and functions.
树突状细胞是一种造血细胞，专门负责抗原呈递和指导先天和适应性免疫反应。它们是一群异质性细胞，存在于淋巴器官和大多数组织中。树突状细胞通常分为三个主要亚群，它们在发育途径、表型和功能上有所不同。大多数关于树突状细胞的研究主要是在小鼠中进行的；因此，在本章中，我们旨在总结目前关于小鼠树突状细胞亚群发育、表型和功能的知识和最新进展。
