Segura Elodie
Institut Curie, 26 rue d'Ulm, 75248, Paris Cedex 05, France.
INSERM U932, 26 rue d'Ulm, 75248, Paris Cedex 05, France.
Methods Mol Biol. 2016;1423:3-15. doi: 10.1007/978-1-4939-3606-9_1.
Dendritic cells are specialized antigen-presenting cells that initiate and orient immune responses. Numerous studies in mice and humans have shown that dendritic cells are heterogeneous and comprise several subsets that can be distinguished by their surface phenotype, ontogeny, and molecular signature. This review gives an overview of mouse and human dendritic cell subsets and their defining features and summarizes the current knowledge of dendritic cell subsets' functional specialization in terms of antigen presentation.
树突状细胞是启动和引导免疫反应的特殊抗原呈递细胞。在小鼠和人类中进行的大量研究表明，树突状细胞具有异质性，由几个亚群组成，这些亚群可通过其表面表型、个体发生和分子特征来区分。本综述概述了小鼠和人类树突状细胞亚群及其定义特征，并就抗原呈递方面总结了目前关于树突状细胞亚群功能特化的知识。
