人群血浆铁蛋白浓度：人体测量学、代谢和饮食相关性的横断面分析。
Plasma Ferritin Concentrations in the General Population: A Cross-Sectional Analysis of Anthropometric, Metabolic, and Dietary Correlates.
机构信息
Institute of Epidemiology, Kiel University, Kiel, Germany.
Institute of Human Nutrition and Food Science, Kiel University, Kiel, Germany.
出版信息
J Nutr. 2023 May;153(5):1524-1533. doi: 10.1016/j.tjnut.2023.03.008. Epub 2023 Mar 10.
BACKGROUND
Elevated concentrations of ferritin seem to be detrimental to human health while being quite common in the elderly. Data on dietary, anthropometric, and metabolic correlates of circulating ferritin levels in the elderly are scant.
OBJECTIVES
We aimed to identify a dietary pattern, anthropometric, and metabolic traits associated with plasma ferritin status in an elderly cohort (n = 460, 57% male, age: 66 ± 12 y) from Northern Germany.
METHODS
Plasma ferritin levels were measured by immunoturbidimetry. Reduced rank regression (RRR) yielded a dietary pattern explaining 13% of the variation in circulating ferritin concentrations. Cross-sectional associations of anthropometric and metabolic traits with plasma ferritin concentrations were assessed using multivariable-adjusted linear regression analysis. Restricted cubic spline regression was used to identify nonlinear associations.
RESULTS
The RRR pattern was characterized by a high intake of potatoes, certain vegetables, beef, pork, processed meat, fats (frying and animal fat), and beer and a low intake of snacks, representing elements of the traditional German diet. BMI, waist circumference, and CRP were directly, HDL cholesterol inversely, and age nonlinearly associated with plasma ferritin concentrations (all P < 0.05). After additional adjustment for CRP, only the association of ferritin with age remained statistically significant.
CONCLUSION
Higher plasma ferritin concentrations were associated with a traditional German dietary pattern. The associations of ferritin with unfavorable anthropometric traits and low HDL cholesterol were rendered statistically nonsignificant upon additional adjustment for chronic systemic inflammation (measured as elevated biomarker of the measurement of inflammation (CRP)), suggesting that these associations were largely driven by the proinflammatory role of ferritin (an acute-phase reactant).
背景
铁蛋白浓度升高似乎对人体健康有害，而在老年人中却很常见。关于老年人循环铁蛋白水平的饮食、人体测量和代谢相关性的数据很少。
目的
我们旨在确定与德国北部老年队列（n = 460，57%为男性，年龄：66 ± 12 岁）血浆铁蛋白状态相关的饮食模式、人体测量和代谢特征。
方法
通过免疫比浊法测量血浆铁蛋白水平。降秩回归（RRR）得出了一个解释循环铁蛋白浓度变化 13%的饮食模式。使用多变量调整线性回归分析评估人体测量和代谢特征与血浆铁蛋白浓度的横断面关联。使用受限立方样条回归来识别非线性关联。
结果
RRR 模式的特点是高土豆、某些蔬菜、牛肉、猪肉、加工肉、脂肪（油炸和动物脂肪）和啤酒的摄入量，以及零食的摄入量低，代表了传统德国饮食的元素。BMI、腰围和 CRP 与血浆铁蛋白浓度呈直接相关，HDL 胆固醇呈负相关，年龄呈非线性相关（均 P < 0.05）。在进一步调整 CRP 后，只有铁蛋白与年龄的关联具有统计学意义。
结论
较高的血浆铁蛋白浓度与传统的德国饮食模式有关。铁蛋白与不良人体测量特征和低 HDL 胆固醇的关联在进一步调整慢性系统性炎症（以升高的炎症标志物（CRP）测量）后变得无统计学意义，表明这些关联主要是由铁蛋白的促炎作用（急性相反应物）驱动的。
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