Moenning Jan-Louis, Numata Jorge, Bloch Dorit, Jahnke Anne, Schafft Helmut A, Spolders Markus, Lüth Anja, Lahrssen-Wiederholt Monika, Schulz Kirsten
German Federal Institute for Risk Assessment, Berlin, Germany.
German Federal Institute for Risk Assessment, Berlin, Germany.
Environ Toxicol Pharmacol. 2023 Apr;99:104106. doi: 10.1016/j.etap.2023.104106. Epub 2023 Mar 11.
Polychlorinated biphenyls (PCBs) are persistent environmental pollutants that accumulate in tissues of exposed animals and humans. This case report refers ton=3 dairy cows accidentally exposed to non-dioxin-like PCBs (ndl-PCBs) of unknown origin on a German farm. At study start they had a cumulative total of 122-643 ng/g fat in milk and 105-591 ng/g fat in blood, consisting mainly of PCBs 138, 153, and 180. Two cows calved during the study and their calves were raised on their mothers' milk, resulting in cumulative exposure until slaughter. A physiologically based toxicokinetic model was developed to describe the fate of ndl-PCBs in the animals. The toxicokinetic behavior of ndl-PCBs was simulated in individual animals, including transfer of contaminants into calves via milk and placenta. Both the simulations and experimental data indicate that contamination via both routes is significant. In addition, the model was used to estimate kinetic parameters for risk assessment.
多氯联苯（PCBs）是持久性环境污染物，会在接触到的动物和人类组织中蓄积。本病例报告涉及德国一家农场中3头奶牛意外接触来源不明的非二噁英类多氯联苯（ndl-PCBs）的情况。在研究开始时，它们的牛奶中脂肪中多氯联苯的累积总量为122 - 643纳克/克，血液中脂肪中多氯联苯的累积总量为105 - 591纳克/克，主要成分是多氯联苯138、153和180。在研究期间，有2头奶牛产犊，它们的犊牛以母乳饲养，直至屠宰，导致犊牛累积接触多氯联苯。建立了基于生理学的毒代动力学模型来描述动物体内ndl-PCBs的归宿。在个体动物中模拟了ndl-PCBs的毒代动力学行为，包括污染物通过乳汁和胎盘向犊牛的转移。模拟结果和实验数据均表明，通过这两种途径的污染都很显著。此外，该模型用于估计风险评估的动力学参数。
