Department of Cardiovascular Surgery, Mount Sinai Morningside, New York, NY, USA; Sydney Medical School, The University of Sydney, Sydney, NSW, Australia.
Department of Cardiothoracic Surgery, Royal North Shore Hospital, Sydney, NSW, Australia.
Heart Lung Circ. 2023 May;32(5):645-651. doi: 10.1016/j.hlc.2023.01.014. Epub 2023 Mar 10.
There is ongoing debate regarding the optimal strategy and timing for the surgical management of patients with severe concomitant carotid and coronary artery disease. Anaortic off-pump coronary artery bypass (anOPCAB), which avoids aortic manipulation and cardiopulmonary bypass, has been shown to reduce the risk of perioperative stroke. We present the outcomes of a series of synchronous carotid endarterectomy (CEA) and anOPCAB.
A retrospective review was performed. The primary endpoint was stroke at 30 days post-operation. Secondary endpoints included transient ischaemic attack, myocardial infarction and mortality 30 days post-operation.
From 2009 to 2016, 1,041 patients underwent anOPCAB with a 30-day stroke rate of 0.4%. The majority of patients had preoperative carotid-subclavian duplex ultrasound screening and 39 were identified with significant concomitant carotid disease who underwent synchronous CEA-anOPCAB. The mean age was 71±7.5 years. Nine patients (23.1%) had previous neurological events. Thirty (30) patients (76.9%) underwent an urgent operation. For CEA, a conventional longitudinal carotid endarterectomy with patch angioplasty was performed in all patients. For anOPCAB, total arterial revascularisation rate was performed in 84.6% and the mean number of distal anastomoses was 2.9±0.7. In the 30-day postoperative period, there was one stroke (2.63%), two deaths (5.26%), two transient ischaemic attacks (TIAs) (5.26%) and no myocardial infarction. Two patients experienced acute kidney injury (5.26%), one of which required haemodialysis (2.63%). Mean length of stay was 11.37±7.9 days.
Synchronous CEA and anOPCAB is a safe and effective option for patients' severe concomitant disease. Preoperative carotid-subclavian ultrasound screening allows identification of these patients.
对于同时患有严重颈动脉和冠状动脉疾病的患者,手术治疗的最佳策略和时机仍存在争议。避免主动脉操作和体外循环的非体外循环冠状动脉旁路移植术(anOPCAB)已被证明可降低围手术期中风的风险。我们介绍了一系列同步颈动脉内膜切除术(CEA)和 anOPCAB 的结果。
进行了回顾性研究。主要终点是术后 30 天的中风。次要终点包括术后 30 天的短暂性脑缺血发作、心肌梗死和死亡率。
2009 年至 2016 年,1041 例行 anOPCAB 手术,术后 30 天的中风发生率为 0.4%。大多数患者接受了术前颈动脉-锁骨下双功能超声筛查,39 例患者被发现有明显的同时性颈动脉疾病,行同步 CEA-anOPCAB。平均年龄为 71±7.5 岁。9 例(23.1%)有既往神经事件。30 例(30%)患者(76.9%)行紧急手术。CEA 手术中所有患者均行传统的纵向颈动脉内膜切除术和补片血管成形术。anOPCAB 中,全动脉血运重建率为 84.6%,远端吻合口平均数量为 2.9±0.7。术后 30 天内,发生 1 例中风(2.63%)、2 例死亡(5.26%)、2 例短暂性脑缺血发作(5.26%)和无心肌梗死。2 例患者发生急性肾损伤(5.26%),其中 1 例需要血液透析(2.63%)。平均住院时间为 11.37±7.9 天。
同步 CEA 和 anOPCAB 是治疗严重合并疾病患者的安全有效的选择。术前颈动脉-锁骨下超声筛查可识别这些患者。