与炎症性肠病相关的生活方式因素：来自瑞士 IBD 队列研究的数据。
Lifestyle factors associated with inflammatory bowel disease: data from the Swiss IBD cohort study.
机构信息
Department of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, Raemistrasse 100, 8091, Zurich, Switzerland.
Institute of Social and Preventive Medicine, Université de Lausanne, Lausanne, Switzerland.
出版信息
BMC Gastroenterol. 2023 Mar 12;23(1):71. doi: 10.1186/s12876-023-02692-9.
BACKGROUND
Various environmental risk factors have been associated with the pathogenesis of inflammatory bowel disease. In this study we aimed to identify lifestyle factors that affect the onset of Crohn's disease and ulcerative colitis.
METHODS
2294 patients from the Swiss IBD Cohort Study received a questionnaire regarding physical activity, nutritional habits and status of weight. In addition, a control group was formed comprising patients' childhood friends, who grew up in a similar environment.
RESULTS
Overall, 1111 questionnaires were returned (response rate: 48.4%). Significantly more patients with inflammatory bowel disease reported no regular practice of sport during childhood and beginning of adulthood compared to the control group (p = 0.0001). No association between intake of refined sugar and onset of inflammatory bowel disease was observed. More patients with Crohn's disease compared to ulcerative colitis and controls suffered from overweight during childhood (12.8% vs. 7.7% and 9.7%, respectively; p = 0.027).
CONCLUSIONS
Our study underlines the relevance of environmental factors in the development of inflammatory bowel disease. Our results imply a protective effect of physical activity regarding the onset of inflammatory bowel disease.
背景
多种环境风险因素与炎症性肠病的发病机制有关。在这项研究中，我们旨在确定影响克罗恩病和溃疡性结肠炎发病的生活方式因素。
方法
瑞士 IBD 队列研究中的 2294 名患者收到了一份关于体育活动、营养习惯和体重状况的问卷。此外，还组成了一个对照组，由在相似环境中长大的患者儿时的朋友组成。
结果
总体而言，共收回 1111 份问卷（回复率：48.4%）。与对照组相比，患有炎症性肠病的患者报告在儿童期和成年早期没有定期进行体育锻炼的明显更多（p=0.0001）。摄入精制糖与炎症性肠病的发病没有关联。与对照组相比，更多的克罗恩病患者在儿童期超重（12.8%比 7.7%和 9.7%；p=0.027）。
结论
我们的研究强调了环境因素在炎症性肠病发展中的重要性。我们的结果表明，体育活动对炎症性肠病的发病有保护作用。
Zotero 插件