Student Research Committee, Department of Biostatistics, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Prevention of Metabolic Disorders Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
J Clin Hypertens (Greenwich). 2021 Jun;23(6):1205-1211. doi: 10.1111/jch.14238. Epub 2021 Mar 15.
Age is a known predictor of blood pressure (BP); however, the literature mostly includes cross-sectional investigations. This prospective cohort study aimed to decompose the cross-sectional and longitudinal age effects on BP. The secondary data were obtained from the Tehran lipid and glucose study, which comprised six repeated measurements of participants, with median follow-up of 15.8 (interquartile range of 14.2-16.9) years. The sample is representative of the metropolitan area of Tehran, Iran, containing 7,460 participants aged 20-70. The cross-sectional and longitudinal effects of age (age at baseline and aging, respectively) were fitted in the mixed effects models, taking systolic, diastolic, and pulse BPs as response, adjusting for adiposity, smoking, diabetes, and antihypertensive medication, and stratifying for sex and 10-year age-groups. The mean age at baseline was 41.3 (SD = 12.9) years, and 41.7% of the participants were male. Age at baseline and aging were directly associated with BP, aging owned the weaker effect, and the largest distinction were for systolic blood pressure of men aged 40-49 years (0.75 vs 0.10, p-value < .001). Moreover, the aging effects on systolic and diastolic BPs were higher in men than women, in the age groups 40-49 and 30-39 years (0.35 vs 0.10 and 0.30 vs 0.07, p-values < .001), respectively. Adjusting for adiposity remarkably declined the impact of aging on BP, among the < 50 years old.
年龄是血压（BP）的已知预测因子；然而，文献大多包括横断面研究。本前瞻性队列研究旨在分解 BP 的横断面和纵向年龄效应。二次数据来自德黑兰血脂和血糖研究，该研究对参与者进行了六次重复测量，中位随访时间为 15.8 年（四分位距为 14.2-16.9 年）。该样本代表了伊朗德黑兰大都市区，包含 7460 名年龄在 20-70 岁的参与者。在混合效应模型中拟合了年龄的横断面和纵向效应（分别为基线时的年龄和老化年龄），以收缩压、舒张压和脉搏血压为反应，调整了肥胖、吸烟、糖尿病和抗高血压药物，并按性别和 10 岁年龄组分层。基线时的平均年龄为 41.3（SD=12.9）岁，41.7%的参与者为男性。基线时的年龄和老化与 BP 直接相关，老化的影响较弱，最大的区别在于 40-49 岁男性的收缩压（0.75 对 0.10，p 值<.001）。此外，在 40-49 岁和 30-39 岁年龄组中，男性的老化对收缩压和舒张压的影响高于女性（0.35 对 0.10 和 0.30 对 0.07，p 值<.001）。在<50 岁的人群中，调整肥胖显著降低了老化对 BP 的影响。
