Ahmed Rania Hassan Mostafa, Bayoumy Hassan Awwad, Ashoush Sherif Ahmed, Gabr Wessam Kamal Lotfy
Department of Gynecology and Obstetrics, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Turk J Obstet Gynecol. 2023 Mar 10;20(1):1-7. doi: 10.4274/tjod.galenos.2023.47715.
To assess whether antenatal azithromycin given to pregnant women with vaginal cerclage can reduce preterm birth or not.
We randomized 50 pregnant ladies who underwent cerclage at Ain Shams University Maternity Hospital in group A (receiving 500 mg Azithromycin oral tablets (Zithrokan, Hikma, Egypt) one tablet orally twice daily for three days in 3 courses at 14, 24 and 32 week, plus usual antenatal care) and an identical group B (receiving usual antenatal care). Our primary outcome was gestational age at delivery, and secondary outcomes were birthweight, mode of delivery, and maternal, and perinatal complications. This study was registered on ClinicalTrials.gov with number: NCT04278937.
Pregnancy was more prolonged in the Azithromycin group (delivery at 36.8 weeks vs 34.1 weeks; p=0.017). Also, a higher birthweight was observed in the Azithromycin group (2932.6 gm vs 2401.8 gm; p=0.006). No significant difference was found between the two groups as regards to other outcomes (miscarriage, stillbirth, neonatal intensive care unit admission, antepartum hemorrhage, postpartum pyrexia, need for blood transfusion).
Adding antenatal azithromycin to women undergoing cerclage prolongs pregnancy and reduces the risk of preterm birth, with a slight increase in birthweight.
评估对接受阴道环扎术的孕妇产前使用阿奇霉素是否能降低早产风险。
我们将在艾因夏姆斯大学妇产医院接受环扎术的50名孕妇随机分为A组（在孕14周、24周和32周时，口服500毫克阿奇霉素片（Zithrokan，希克玛，埃及），每日两次，每次一片，共三天，分三个疗程，外加常规产前护理）和相同的B组（接受常规产前护理）。我们的主要结局是分娩时的孕周，次要结局是出生体重、分娩方式以及母体和围产期并发症。本研究已在ClinicalTrials.gov上注册，注册号为：NCT04278937。
阿奇霉素组的孕期延长更多（分别为36.8周分娩与34.1周分娩；p = 0.017）。此外，阿奇霉素组观察到更高出生体重（分别为2932.6克与2401.8克；p = 0.006）。两组在其他结局（流产、死产、新生儿重症监护病房入院、产前出血、产后发热、输血需求）方面未发现显著差异。
对接受环扎术的女性产前加用阿奇霉素可延长孕期并降低早产风险，出生体重略有增加。
