Department of Agricultural Biotechnology, National Agri-Food Biotechnology Institute (NABI), Mohali, Punjab, India.
Department of Biochemistry, Panjab University, Chandigarh, India.
Crit Rev Food Sci Nutr. 2024 Jul;64(21):7517-7534. doi: 10.1080/10408398.2023.2186121. Epub 2023 Mar 12.
Anthocyanins have been reported for the protective effects against type 2 diabetes and related obesity. This meta-analysis examined the benefits of anthocyanins on type 2 diabetes and obesity biomarkers in animals and humans. The study included 21 clinical trials and 27 pre-clinical studies. A systematic search was conducted using the following inclusion criteria: in vivo rodent studies; human randomized clinical trials, both aimed at assessing the fasting blood glucose (FBG), HbA1c, total cholesterol, triglycerides, high-density lipoprotein and low-density lipoprotein; and study duration of at least two weeks. Out of the 201 examined publications, 48 were shortlisted after implementation of the selection criteria. Results of clinical trials demonstrated that consumption of anthocyanin-rich food significantly reduced the FBG ( < 0.0001), HbA1c ( = 0.02), TC ( = 0.010), TG ( = 0.003), LDL ( = 0.05) and increases the HDL ( = 0.03) levels. Similarly, pre-clinical studies demonstrated the amelioration of the HbA1c ( = 0.02), FBG, TC, TG, and LDL ( < 0.00001), with non-significant changes in the HDL ( = 0.11). Sub-group analysis indicated dose-dependent effect. This compilation confirms that consuming anthocyanin-rich foods positively correlates with the reduction in the blood glucose and lipid levels in diabetic and obese subjects.
花色苷已被报道具有预防 2 型糖尿病和相关肥胖的作用。本荟萃分析研究了花色苷对动物和人类 2 型糖尿病和肥胖生物标志物的有益作用。该研究纳入了 21 项临床试验和 27 项临床前研究。采用以下纳入标准进行了系统检索：体内啮齿动物研究；旨在评估空腹血糖（FBG）、HbA1c、总胆固醇、甘油三酯、高密度脂蛋白和低密度脂蛋白的人类随机临床试验；以及研究持续时间至少两周。在检查的 201 篇出版物中，实施选择标准后，有 48 篇被列入候选名单。临床试验结果表明，食用富含花色苷的食物可显著降低 FBG（ < 0.0001）、HbA1c（ = 0.02）、TC（ = 0.010）、TG（ = 0.003）、LDL（ = 0.05），并升高 HDL（ = 0.03）水平。同样，临床前研究表明可改善 HbA1c（ = 0.02）、FBG、TC、TG 和 LDL（ < 0.00001），而 HDL（ = 0.11）无显著变化。亚组分析表明存在剂量依赖性效应。本综述证实，食用富含花色苷的食物与降低糖尿病和肥胖患者的血糖和血脂水平呈正相关。
