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急性胰腺炎合并上消化道梗阻后发生韦尼克脑病:一例报告及文献复习

Wernicke's encephalopathy after acute pancreatitis with upper gastrointestinal obstruction: A case report and literature review.

作者信息

Wang Zongding, Zhang Lei, Deng Xingzhen, Peng Zili, Liang Shaoyong

机构信息

Department of Hepatobiliary Surgery, Fengjie County People's Hospital of Chongqing, Chongqing, China.

Department of Hepatobiliary Surgery, Fengjie Hospital, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.

出版信息

Front Neurol. 2023 Feb 23;14:1108434. doi: 10.3389/fneur.2023.1108434. eCollection 2023.

DOI:10.3389/fneur.2023.1108434
PMID:36908626
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9996226/
Abstract

A 42-year-old female was admitted with upper abdominal pain. Imaging studies and laboratory tests were performed to consider acute lipogenic pancreatitis. After symptomatic treatment, her abdominal pain was significantly relieved. However, the patient was accompanied by upper gastrointestinal obstruction, which was gradually relieved after long-term fasting, gastrointestinal decompression, and fluid rehydration. The patient developed dizziness and ataxia, which worsened. Cranial magnetic resonance imaging (MRI) indicated patchy abnormal signal shadows in the bilateral thalami and dorsal brainstem and suggested metabolic encephalopathy. Wernicke's encephalopathy (WE) was the initial diagnosis of suspicion, adequate vitamin B1 was immediately replenished until the complete resolution of symptoms, and the patient made a rapid and dramatic recovery.

摘要

一名42岁女性因上腹部疼痛入院。进行了影像学检查和实验室检查以考虑急性脂源性胰腺炎。经过对症治疗,她的腹痛明显缓解。然而,该患者伴有上消化道梗阻,经过长期禁食、胃肠减压和补液后逐渐缓解。患者出现头晕和共济失调,且病情加重。头颅磁共振成像(MRI)显示双侧丘脑和脑桥背侧有斑片状异常信号影,提示代谢性脑病。初步怀疑诊断为韦尼克脑病(WE),立即补充足够的维生素B1直至症状完全缓解,患者迅速显著康复。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4322/9996226/980a08109311/fneur-14-1108434-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4322/9996226/a8246fe3e39d/fneur-14-1108434-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4322/9996226/92d27e7eaee6/fneur-14-1108434-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4322/9996226/980a08109311/fneur-14-1108434-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4322/9996226/a8246fe3e39d/fneur-14-1108434-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4322/9996226/92d27e7eaee6/fneur-14-1108434-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4322/9996226/980a08109311/fneur-14-1108434-g0003.jpg

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Drugs. 2022 Aug;82(12):1251-1276. doi: 10.1007/s40265-022-01766-4. Epub 2022 Sep 8.
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Revised Clinical Practice Guidelines of the Korean Pancreatobiliary Association for Acute Pancreatitis.韩国胰腺病学会急性胰腺炎临床实践指南修订版。
Gut Liver. 2023 Jan 15;17(1):34-48. doi: 10.5009/gnl220108. Epub 2022 Aug 17.
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[Prediction and diagnosis of pancreatogenic encephalopathy in patients with destructive pancreatitis].[破坏性胰腺炎患者胰源性脑病的预测与诊断]
Khirurgiia (Mosk). 2022(7):58-63. doi: 10.17116/hirurgia202207158.
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Managing severe acute and necrotizing pancreatitis.重症急性和坏死性胰腺炎的管理
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Pediatr Int. 2022 Jan;64(1):e15145. doi: 10.1111/ped.15145.
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Investigation and management of Wilson's disease: a practical guide from the British Association for the Study of the Liver.威尔逊病的调查与管理:来自英国肝脏研究协会的实用指南。
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