Sanromán Á F, Joshi K, Au L, Chain B, Turajlic S
Cancer Dynamics Laboratory, The Francis Crick Institute, London, UK.
Department of Medical Oncology, The Royal Marsden NHS Foundation Trust, London, UK.
Immunooncol Technol. 2023 Feb 4;17:100373. doi: 10.1016/j.iotech.2023.100373. eCollection 2023 Mar.
•T-cell receptor (TCR) interaction with major histocompatibility complex-antigen complexes leads to antitumour responses.•TCR sequencing analysis allows characterisation of T cells that recognise tumour neoantigens.•T-cell clonal revival and clonal replacement potentially underpin immunotherapy responses.
•T细胞受体（TCR）与主要组织相容性复合体-抗原复合物的相互作用会引发抗肿瘤反应。
•TCR测序分析能够对识别肿瘤新抗原的T细胞进行特征描述。
•T细胞克隆复苏和克隆替代可能是免疫治疗反应的基础。
