心血管疾病中骨形态发生蛋白的研究进展
Insights into bone morphogenetic proteins in cardiovascular diseases.
作者信息
Ye Di, Liu Yinghui, Pan Heng, Feng Yongqi, Lu Xiyi, Gan Liren, Wan Jun, Ye Jing
机构信息
Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China.
Cardiovascular Research Institute, Wuhan University, Wuhan, China.
出版信息
Front Pharmacol. 2023 Feb 23;14:1125642. doi: 10.3389/fphar.2023.1125642. eCollection 2023.
Abstract
Bone morphogenetic proteins (BMPs) are secretory proteins belonging to the transforming growth factor-β (TGF-β) superfamily. These proteins play important roles in embryogenesis, bone morphogenesis, blood vessel remodeling and the development of various organs. In recent years, as research has progressed, BMPs have been found to be closely related to cardiovascular diseases, especially atherosclerosis, vascular calcification, cardiac remodeling, pulmonary arterial hypertension (PAH) and hereditary hemorrhagic telangiectasia (HHT). In this review, we summarized the potential roles and related mechanisms of the BMP family in the cardiovascular system and focused on atherosclerosis and PAH.
摘要
骨形态发生蛋白（BMPs）是属于转化生长因子-β（TGF-β）超家族的分泌蛋白。这些蛋白在胚胎发生、骨形态发生、血管重塑及各种器官的发育中发挥重要作用。近年来，随着研究的进展，发现BMPs与心血管疾病密切相关，尤其是动脉粥样硬化、血管钙化、心脏重塑、肺动脉高压（PAH）和遗传性出血性毛细血管扩张症（HHT）。在本综述中，我们总结了BMP家族在心血管系统中的潜在作用及相关机制，并重点关注动脉粥样硬化和PAH。
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