Department of Endocrinology, The First Medical Center, Chinese People's Liberation Army (PLA) General Hospital, Beijing, China.
Department of Endocrinology, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou, China.
Front Endocrinol (Lausanne). 2023 Feb 27;14:1081520. doi: 10.3389/fendo.2023.1081520. eCollection 2023.
The hemoglobin glycation index (HGI) quantifies the mismatch between glycated hemoglobin A1c and average glycemia among individuals. Currently, it is unknown the potential role of HGI in exhaustively evaluating the progression of glucose metabolism/the risk of developing diabetes mellitus. Therefore, this study aimed to investigate the association between HGI and the risk of incident diabetes.
A total of 7,345 participants aged at least 40 years and without diabetes were divided into three groups according to the tertile of their baseline HGI level and followed for a median of 3.24 years to track new-onset diabetes. Using multivariate Cox regression analyses, we explored the association between the HGI, both categorized and continuous, and incident diabetes.
During follow-up, 742 subjects (263 males and 479 females) developed diabetes mellitus. Higher HGI was associated with an increased risk of diabetes, even when adjusted for confounding factors, and every standard deviation increase in HGI was associated with a significant risk increase of 30.6% for diabetes (hazard ratio 1.306, 95% confidence interval 1.232-1.384).
Participants with a higher HGI were at a higher risk of future diabetes, irrespective of their glycemic conditions. Consequently, HGI may be employed to identify individuals at high risk for diabetes.
血红蛋白糖基化指数（HGI）量化了个体糖化血红蛋白 A1c 与平均血糖之间的不匹配程度。目前，尚不清楚 HGI 在全面评估葡萄糖代谢进展/发生糖尿病的风险方面的潜在作用。因此，本研究旨在探讨 HGI 与发生糖尿病的风险之间的关系。
共有 7345 名年龄至少 40 岁且无糖尿病的参与者根据基线 HGI 水平的三分位将其分为三组，并随访中位数为 3.24 年，以跟踪新发生的糖尿病。我们使用多变量 Cox 回归分析探讨了 HGI（分类和连续）与新发糖尿病之间的关系。
在随访期间，742 名受试者（263 名男性和 479 名女性）发生了糖尿病。即使在调整了混杂因素后，较高的 HGI 与糖尿病风险增加相关，HGI 每增加一个标准差，糖尿病的风险显著增加 30.6%（风险比 1.306，95%置信区间 1.232-1.384）。
无论血糖状况如何，HGI 较高的参与者未来发生糖尿病的风险更高。因此，HGI 可用于识别发生糖尿病风险较高的个体。
