Yousseu Nana William, Billong Mimb Justin Rodrigue, Atsamo Albert Donatien, Tsafack Eric Gonzal, Djuichou Nguemnang Stephanie Flore, Fagni Njoya Zenab Linda, Matah Marthe Vanessa Mba, Madjo Kouam Yacine Karelle, Mbiantcha Marius, Ateufack Gilbert
Laboratory of Biology and Physiology of Animal Organisms, Department of Biology of Animal Organisms, Faculty of Science, The University of Douala Cameroon, P.O. Box 24157, Douala, Cameroon.
Research Unit of Animal Physiology and Phytopharmacology, Faculty of Science, University of Dschang, Dschang, Cameroon.
Int J Inflam. 2023 Mar 1;2023:7915367. doi: 10.1155/2023/7915367. eCollection 2023.
In traditional Cameroonian medicine, to relieve many inflammations, parts of , are very widely used. This study considered the evaluation of acute toxicity and anti-inflammatory properties of the hydroethanolic extract of the roots of . In an acute toxicity study, 250, 2500, and 5000 mg/kg were administered orally to mice in a single dose, and general behavior, adverse effects, and mortality were monitored. and anti-inflammatory tests were performed, and then histological, serum, hematological, and oxidative stress parameters have been evaluated. In an acute toxicity, all groups revealed neither mortality nor any significant alteration in behavior; only drowsiness, sedation, and lethargy were observed at 5000 mg/kg. For tests, the extract inhibited anti-inflammatory activity. In the formalin test, at 250 mg/kg, the extract inhibited edema with a percentage of 56.41% (4 hour) in an acute treatment and 74.44% (10 day). Joint edema was reduced by 67.24% (24 hour) in a single treatment and by 74.25% (7 day) in repeated treatment. The extract caused an increase in red blood cell, hemoglobin, and serum protein levels and reduced the white blood cells as well as the activities of alkaline phosphatase and alanine aminotransferase. The extract modulated oxidative stress parameters in the brain, spinal cord, liver, and kidneys. The extract protected the joint by reducing the bone and cartilage erosion. The present work highlights the anti-inflammatory, antioxidant, and antianemic properties of the hydroethanolic extract of the roots of , which supports its empirical use in traditional medicine for the treatment of inflammatory pathologies.
在喀麦隆传统医学中，为缓解多种炎症，[植物名称]的部分部位被广泛使用。本研究对[植物名称]根的水乙醇提取物的急性毒性和抗炎特性进行了评估。在急性毒性研究中，以250、2500和5000毫克/千克的单一剂量口服给予小鼠，监测其一般行为、不良反应和死亡率。进行了[具体抗炎实验名称1]和[具体抗炎实验名称2]抗炎试验，然后评估了组织学、血清学、血液学和氧化应激参数。在急性毒性实验中，所有组均未出现死亡，行为也无任何显著改变；仅在5000毫克/千克剂量时观察到嗜睡、镇静和昏睡。对于[具体抗炎实验名称1]试验，该提取物抑制了抗炎活性。在福尔马林试验中，在急性治疗时，250毫克/千克剂量的提取物在4小时时抑制水肿的百分比为56.41%，在10天时为74.44%。单次治疗时关节水肿在24小时时减少了67.24%，重复治疗7天时减少了74.25%。该提取物使红细胞、血红蛋白和血清蛋白水平升高，同时降低了白细胞以及碱性磷酸酶和丙氨酸转氨酶的活性。该提取物调节了脑、脊髓、肝脏和肾脏中的氧化应激参数。该提取物通过减少骨和软骨侵蚀来保护关节。本研究突出了[植物名称]根的水乙醇提取物的抗炎、抗氧化和抗贫血特性，这支持了其在传统医学中用于治疗炎症性疾病的经验性应用。
