Bhanjadeo Rojali, Patra R C, Panda Dibya, Sahoo Rajasri, Das D P, Mohanty B N
Department of Veterinary Clinical Medicine, College of Veterinary Science and Animal Husbandry, Odisha University of Agriculture and Technology, Bhubaneswar, 751003 India.
Department of Veterinary Parasitology, College of Veterinary Science and Animal Husbandry, Odisha University of Agriculture and Technology, Bhubaneswar, 751003 India.
J Parasit Dis. 2023 Mar;47(1):37-45. doi: 10.1007/s12639-022-01536-9. Epub 2022 Oct 12.
The present experiment was carried out to assess the comparative efficacy of ivermectin and fenbendazole individually for anthelmintic therapy for the hookworm infested dogs. Dogs presented to the Department of Veterinary Clinical Medicine or Veterinary Clinical Complex, Bhubaneswar were randomly screened for infection and the positive dogs were selected for the therapeutic trial Faecal samples were collected randomly from presented dogs immediately after defaecation or from the rectum directly using a faecal scoop. The collected sample was examined by floatation technique to detect the positive cases of infection. The dogs with normal clinical parameters and no eggs or ova in the faeces were included in in group 1 ( = 12). Dogs with faecal sample positive for ova were recruited for the comparative study ( = 24) which were grouped into two groups consisting of 12 dogs in each (group 2 and 3). Group 2 dogs ( = 12) were treated with ivermectin at 200 µg/kg body weight once orally repeated after 15 days with proper supportive therapy each time. Group 3 ( = 12) were treated with fenbendazole at 50 mg/kg body weight once orally repeated after 15 days with proper supportive therapy each time. Haematological examinations and serum biochemical tests were carried out in all groups each time on day 0, 15 and 30 of the experiment. The therapeutic efficacy of both the drugs was calculated on the basis of number of animals found free of infection as determined by reduction in EPG count of the faeces of the group following the treatment. The reduction in eggs per gram (EPG) count on day 15 and day 30 was more significant in group 2 than group 3. The mean EPG count reduced significantly to 24.17 ± 11.44 on day 15 from day 0 level of 1650.00 ± 247.25 in fenbendazole-treated dogs. On day 30, the mean value further reduced to become nil.The 15th day after treatment, mean (± SE) value of protein, albumin and globulin was changed to 5.63 ± 0.12, 2.64 ± 0.12 and 2.99 ± 0.15 g/dl, respectively. The 30th day after treatment, the values were 6.23 ± 0.14, 3.20 ± 0.18 and 3.03 ± 0.21 g/dl, respectively. The total protein and albumin values were significantly changed from day 0 level in group 2 and 3 by 15th day and 30th day, respectively, at 1% level of significance. Following treatment with ivermectin, the 15th day haematological values increased significantly at 1% level ( < 0.01) of significance. There was significant increase in the values at 1% level on the 30th day compared to day 0 and the mean values were non-significantly comparable to the healthy control group except PCV and TEC.
本实验旨在评估伊维菌素和芬苯达唑分别用于治疗钩虫感染犬的驱虫效果。将送至布巴内斯瓦尔兽医临床医学系或兽医临床综合大楼的犬只随机进行感染筛查，选择阳性犬只进行治疗试验。粪便样本在犬只排便后立即随机采集，或直接用粪便勺从直肠采集。采集的样本通过漂浮技术检测感染阳性病例。临床参数正常且粪便中无虫卵的犬只纳入第1组（n = 12）。粪便样本虫卵阳性的犬只被招募进行比较研究（n = 24），分为两组，每组12只（第2组和第3组）。第2组犬只（n = 12）以200 μg/kg体重口服伊维菌素一次，15天后重复给药，每次均给予适当的支持治疗。第3组（n = 12）以50 mg/kg体重口服芬苯达唑一次，15天后重复给药，每次均给予适当的支持治疗。在实验的第0、15和30天，对所有组进行血液学检查和血清生化检测。两种药物的治疗效果根据治疗后该组粪便EPG计数降低所确定的无感染动物数量来计算。第15天和第30天，第2组的每克虫卵数（EPG）计数降低比第3组更显著。芬苯达唑治疗的犬只，EPG计数从第0天的1650.00±247.25显著降至第15天的24.17±11.44。在第30天，平均值进一步降至零。治疗后第15天，蛋白质、白蛋白和球蛋白的平均值（±标准误）分别变为5.63±0.12、2.64±0.12和2.99±0.15 g/dl。治疗后第30天，这些值分别为6.23±0.14、3.20±0.18和3.03±0.21 g/dl。第2组和第3组的总蛋白和白蛋白值在第15天和第30天分别与第0天水平相比有显著变化，显著性水平为1%。用伊维菌素治疗后，第15天血液学值在1%显著性水平（P < 0.01）下显著升高。与第0天相比，第30天这些值在1%水平上有显著升高，除红细胞压积和红细胞总数外，平均值与健康对照组无显著差异。
