IL-4R Q576R 多态性与儿童哮喘的关联：一项荟萃分析。

Association of the IL-4R Q576R Polymorphism with Pediatric Asthma: a meta-analysis.

机构信息

Department of Pediatrics, Huangshi Central Hospital, Affiliated Hospital of Hubei Polytechnic University, Edong Healthcare Group, Huangshi, Hubei 435000, China.

出版信息

Afr Health Sci. 2022 Sep;22(3):307-316. doi: 10.4314/ahs.v22i3.32.

DOI:10.4314/ahs.v22i3.32

PMID:36910341

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9993270/

Abstract

BACKGROUND

The relationship between Q576R polymorphism of IL-4 receptor (IL-4R) gene and pediatric asthma risk is still undefined. To this end, this meta-analysis was performed to explore the above controversy.

METHODS

In this study, we systemically retrieved CNKI, EMBASE, Web of Science, Scopus, Science direct and Pub Med to collect relevant researches, followed by calculation of odds ratio (OR) along with 95% confidence intervals (CIs). STATA 12.0 software was employed in this meta-analysis.

RESULTS

We found an association between IL-4R Q576R polymorphism and pediatric asthma risk (GG vs AA: OR = 3.75, 95% CI = 1.89-7.45; AG vs AA: OR = 2.15, 95% CI = 1.36-3.39; the dominant model: OR = 2.25, 95% CI = 1.42-3.57;the recessive model: OR = 3.05, 95% CI = 1.54-6.05). Moreover, there was no obvious publication bias.

CONCLUSION

Our findings suggested that G allele of IL-4R Q576R polymorphism is associated with increased risk of pediatric asthma. Anyhow, delicately-designed, large-scale studies should be conducted to further confirm the current outcomes.

摘要

背景

白细胞介素 4 受体（IL-4R）基因 Q576R 多态性与儿童哮喘风险之间的关系仍未确定。为此，进行了这项荟萃分析，以探讨上述争议。

方法

本研究系统检索了中国知网、EMBASE、Web of Science、Scopus、Science Direct 和 Pub Med，以收集相关研究，随后计算了比值比（OR）及其 95%置信区间（CI）。本荟萃分析采用 STATA 12.0 软件。

结果

我们发现 IL-4R Q576R 多态性与儿童哮喘风险之间存在关联（GG 与 AA：OR=3.75，95%CI=1.89-7.45；AG 与 AA：OR=2.15，95%CI=1.36-3.39；显性模型：OR=2.25，95%CI=1.42-3.57；隐性模型：OR=3.05，95%CI=1.54-6.05）。此外，不存在明显的发表偏倚。