Jones R N, Barry A L
Clinical Microbiology Institute, Tualatin, OR 97062.
Diagn Microbiol Infect Dis. 1987 May;7(1):77-82. doi: 10.1016/0732-8893(87)90075-7.
Coumermycin was found to be extremely active against methicillin-susceptible and -resistant Staphylococcus spp. (MIC 90, less than or equal to 0.002 microgram/ml). Vancomycin and coumermycin were equally active against Streptococcus spp. (MIC 90s, 0.5 microgram/ml) and both were superior to fusidic acid (MIC 90, 8.0 micrograms/ml). The enterococci had the highest MICs for all three drugs. Disk diffusion susceptibility tests using either 5 or 15 micrograms coumermycin disks seem reliable. The tentative interpretive breakpoints for testing the Staphylococcus spp. only are: 5 micrograms disk-susceptible greater than or equal to 17 and resistant less than or equal to 13 mm; 15 micrograms disk-susceptible greater than or equal to 20 mm and resistant less than or equal to 16 mm. These zone criteria have approximate coumermycin MIC correlates of less than or equal to 0.12 microgram/ml for susceptible and greater than or equal to 0.5 microgram/ml for resistant.
香豆霉素对甲氧西林敏感和耐药的葡萄球菌属表现出极高的活性（MIC90，小于或等于0.002微克/毫升）。万古霉素和香豆霉素对链球菌属的活性相当（MIC90均为0.5微克/毫升），且两者均优于夫西地酸（MIC90为8.0微克/毫升）。所有三种药物对肠球菌的MIC最高。使用5微克或15微克香豆霉素纸片进行的纸片扩散药敏试验似乎可靠。仅针对葡萄球菌属检测的初步解释性断点为：5微克纸片，敏感大于或等于17毫米，耐药小于或等于13毫米；15微克纸片，敏感大于或等于20毫米，耐药小于或等于16毫米。这些抑菌圈标准对应的香豆霉素MIC约为：敏感时小于或等于0.12微克/毫升，耐药时大于或等于0.5微克/毫升。
