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1
Antibacterial activity of coumermycin alone and in combination with other antibiotics.香豆霉素单独及与其他抗生素联合使用时的抗菌活性。
Antimicrob Agents Chemother. 1984 Jun;25(6):687-9. doi: 10.1128/AAC.25.6.687.
2
Comparative in vitro activity of CI934, a new fluoroquinolone, alone and in combination with coumermycin, against gram-positive bacteria.新型氟喹诺酮类药物CI934单独及与香豆霉素联合应用对革兰氏阳性菌的体外比较活性
Drugs Exp Clin Res. 1987;13(3):125-32.
3
Antimicrobial activity of coumermycin and recommendations for disk diffusion tests with 5- and 15-micrograms disks.香豆霉素的抗菌活性及使用5微克和15微克药敏纸片进行纸片扩散法试验的建议
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Comparative in vitro activity of coumermycin against methicillin-resistant Staphylococcus aureus.香豆霉素对耐甲氧西林金黄色葡萄球菌的体外活性比较
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In vitro activity of coumermycin alone or in combination against Staphylococcus aureus and Staphylococcus epidermidis.香豆霉素单独或联合使用对金黄色葡萄球菌和表皮葡萄球菌的体外活性。
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In vitro activity of CI-934 compared with ciprofloxacin, enoxacin, norfloxacin, and vancomycin.CI-934与环丙沙星、依诺沙星、诺氟沙星及万古霉素的体外活性比较。
Diagn Microbiol Infect Dis. 1987 Apr;6(4):301-6. doi: 10.1016/0732-8893(87)90179-9.

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1
Biological evaluation of benzothiazole ethyl urea inhibitors of bacterial type II topoisomerases.细菌II型拓扑异构酶的苯并噻唑乙基脲抑制剂的生物学评价
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Synergy of levofloxacin (L-ofloxacin) and oxacillin against quinolone-resistant Staphylococcus aureus, measured by the time-kill method.采用时间杀菌法测定左氧氟沙星（L-氧氟沙星）与苯唑西林对耐喹诺酮金黄色葡萄球菌的协同作用。
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8
Comparative in vitro activity of LY146032 (daptomycin) against gram-positive cocci.LY146032（达托霉素）对革兰氏阳性球菌的体外活性比较
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9
The fluoroquinolones: structures, mechanisms of action and resistance, and spectra of activity in vitro.氟喹诺酮类药物：结构、作用机制与耐药性以及体外活性谱
Antimicrob Agents Chemother. 1985 Oct;28(4):581-6. doi: 10.1128/AAC.28.4.581.
10
Comparison of the activities of coumermycin, ciprofloxacin, teicoplanin, and other non-beta-lactam antibiotics against clinical isolates of methicillin-resistant Staphylococcus aureus from various geographical locations.香豆霉素、环丙沙星、替考拉宁及其他非β-内酰胺类抗生素对来自不同地理位置的耐甲氧西林金黄色葡萄球菌临床分离株的活性比较。
Antimicrob Agents Chemother. 1985 Nov;28(5):634-8. doi: 10.1128/AAC.28.5.634.

本文引用的文献

1
Antibiotic-resistant group JK bacteria in hospitals.医院内的抗生素耐药性JK菌群
J Clin Microbiol. 1981 Mar;13(3):472-7. doi: 10.1128/jcm.13.3.472-477.1981.
2
Synergism between aminoglycosides and cephalosporins with antipseudomonal activity: interaction index and killing curve method.具有抗假单胞菌活性的氨基糖苷类药物与头孢菌素之间的协同作用：相互作用指数和杀菌曲线法
Antimicrob Agents Chemother. 1982 Nov;22(5):743-52. doi: 10.1128/AAC.22.5.743.
3
The emergence of methicillin-resistant Staphylococcus aureus.耐甲氧西林金黄色葡萄球菌的出现。
Ann Intern Med. 1982 Sep;97(3):440-2. doi: 10.7326/0003-4819-97-3-440.
4
Therapeutic granulocyte transfusions for documented infections. A controlled trial in ninety-five infectious granulocytopenic episodes.治疗性粒细胞输注用于确诊感染。一项针对95例感染性粒细胞减少症发作的对照试验。
Ann Intern Med. 1982 Oct;97(4):509-15. doi: 10.7326/0003-4819-97-4-509.
5
Effects of novobiocin, coumermycin A1, clorobiocin, and their analogs on Escherichia coli DNA gyrase and bacterial growth.新生霉素、香豆霉素A1、氯新生霉素及其类似物对大肠杆菌DNA促旋酶和细菌生长的影响。
Antimicrob Agents Chemother. 1982 Oct;22(4):662-71. doi: 10.1128/AAC.22.4.662.
6
Antistaphylococcal activity of rifampin with other antibiotics.利福平与其他抗生素的抗葡萄球菌活性。
J Infect Dis. 1981 Oct;144(4):365-71. doi: 10.1093/infdis/144.4.365.
7
Pharmacokinetic profile of coumermycin A.香豆霉素A的药代动力学概况。
J Pharm Sci. 1970 Mar;59(3):309-13. doi: 10.1002/jps.2600590306.

香豆霉素单独及与其他抗生素联合使用时的抗菌活性。

Antibacterial activity of coumermycin alone and in combination with other antibiotics.

作者信息

Neu H C, Chin N X, Labthavikul P

出版信息

Antimicrob Agents Chemother. 1984 Jun;25(6):687-9. doi: 10.1128/AAC.25.6.687.

DOI:10.1128/AAC.25.6.687
PMID:6331295
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC185623/
Abstract

Coumermycin has been shown to inhibit Staphylococcus aureus and Staphylococcus epidermidis strains that are susceptible and those that are resistant to methicillin at concentrations less than or equal to 0.05 micrograms/ml. Listeria monocytogenes and Corynebacterium spp. resistant to cephalosporins were inhibited by less than or equal to 1.6 micrograms of coumermycin ml, and streptococcal species, with the exception of Streptococcus faecalis, were inhibited by 0.1 micrograms/ml. Cross-resistance with beta-lactams or aminoglycosides was not found. Coumermycin acted synergistically with ofloxacin, norfloxacin, and enoxacin against S. aureus but did not show synergy when combined with nafcillin, vancomycin, or rifampin. Coumermycin did not inhibit members of the family Enterobacteriaceae or Pseudomonas aeruginosa.

摘要

香豆霉素已被证明在浓度小于或等于0.05微克/毫升时，能抑制对甲氧西林敏感和耐药的金黄色葡萄球菌及表皮葡萄球菌菌株。对头孢菌素耐药的单核细胞增生李斯特菌和棒状杆菌属，在香豆霉素浓度小于或等于1.6微克/毫升时受到抑制，除粪肠球菌外的链球菌属在0.1微克/毫升时受到抑制。未发现与β-内酰胺类或氨基糖苷类有交叉耐药性。香豆霉素与氧氟沙星、诺氟沙星和依诺沙星对金黄色葡萄球菌有协同作用，但与萘夫西林、万古霉素或利福平联合使用时未显示协同作用。香豆霉素不抑制肠杆菌科成员或铜绿假单胞菌。