尼日利亚伊洛林大学教学医院慢性肾脏病患者的功能性铁状态。
Functional iron status of chronic kidney disease patients at the University of Ilorin Teaching Hospital, Ilorin, Nigeria.
机构信息
Department of Haematology, Faculty of Basic Clinical Sciences, Nile University of Nigeria, Abuja, Nigeria.
Department of Haematology, Faculty of Basic Clinical Sciences, University of Ilorin, P.M.B 1515, Ilorin, Nigeria.
出版信息
Afr Health Sci. 2022 Sep;22(3):718-725. doi: 10.4314/ahs.v22i3.77.
BACKGROUND
Functional iron deficiency has been found to be a common cause of poor response to erythropoiesis stimulating agents in anaemic patients with chronic kidney disease (CKD).
OBJECTIVES
Assess the functional iron status of patients with chronic kidney disease.
METHODS
This was a hospital based cross sectional study. The study subjects were chronic kidney disease patients with age and sex matched healthy controls. Full blood count, serum ferritin, soluble transferring receptor, C-reactive protein, serum iron and total iron binding capacity were measured in the patients and healthy controls.Data was analyzed with statistical package for the social sciences software version 22.0. And the level of statistical significance was set at p. value < 0.05.
RESULTS
The mean ± SD of the age of patient with CKD was 55.0 + 15.4 years, while that of controls was 52.7 + 13.6 years. The mean serum ferritin, serum iron, TIBC and CRP were significantly higher in patients compared with controls (p<0.001, 0.023, <0.001 and 0.001) respectively. Functional iron deficiency was seen in 19.5% of patients with CKD.
CONCLUSION
The predominant form of iron deficiency in our study was functional iron deficiency.
背景
功能性缺铁被发现是慢性肾脏病（CKD）贫血患者对红细胞生成刺激剂反应不良的常见原因。
目的
评估慢性肾脏病患者的功能性铁状态。
方法
这是一项基于医院的横断面研究。研究对象为年龄和性别匹配的慢性肾脏病患者和健康对照者。在患者和健康对照者中测量全血细胞计数、血清铁蛋白、可溶性转铁蛋白受体、C 反应蛋白、血清铁和总铁结合力。使用社会科学统计软件包版本 22.0 进行数据分析。并将统计显著性水平设定为 p 值<0.05。
结果
CKD 患者的平均年龄为 55.0±15.4 岁，而对照组为 52.7±13.6 岁。与对照组相比，患者的血清铁蛋白、血清铁、TIBC 和 CRP 均显著升高（p<0.001、0.023、<0.001 和 0.001）。19.5%的 CKD 患者存在功能性缺铁。
结论
在我们的研究中，缺铁的主要形式是功能性缺铁。
Zotero 插件